merck millipore,默克密理愽
  • merck millipore,默克密理博,AB9450,Anti-Metabotropic Glutamate Receptor 6 Antibody

  • merck millipore,默克密理博,AB9450,Anti-Metabotropic Glutamate Receptor 6 Antibody

    产品名称：Anti-Metabotropic Glutamate Receptor 6 Antibody
    产品型号：AB9450
    This Anti-Metabotropic Glutamate Receptor 6 Antibody is validated for use in IH(P) for the detection of Metabotropic Glutamate Receptor 6.

    merck millipore,默克密理博,AB9450,Anti-Metabotropic Glutamate Receptor 6 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB9450,Anti-Metabotropic Glutamate Receptor 6 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    HIH(P)RbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 AB9450
    Replaces AB5826
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Metabotropic Glutamate Receptor 6 Antibody
    产品信息
    格式 Affinity Purified
    演示 Affinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
    应用
    应用 This Anti-Metabotropic Glutamate Receptor 6 Antibody is validated for use in IH(P) for the detection of Metabotropic Glutamate Receptor 6.
    主要应用
    • Immunohistochemistry (Paraffin)
    应用说明 Immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections.

    Western Blot

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Synthetic peptide from the N-terminal extracellular domain of human Metabotropic Glutamate Receptor 6.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Recognizes Metabotropic Glutamate Receptor 6 [mGluR6].
    品种反应性 Human
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_000843.3
    Entrez基因汇总 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
    基因符号
    • mGlu6
    • GRM6
    • DKFZp686H1993
    • GPRC1F
    • mGluR6
    • MGLUR6
    • CSNB1B
    UniProt编号
    • O15303
    UniProt汇总 FUNCTION: SwissProt: O15303 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
    SIZE: 877 amino acids; 95437 Da
    SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
    DISEASE: SwissProt: O15303 # Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B) [MIM:257270]. This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background.
    SIMILARITY: SwissProt: O15303 ## Belongs to the G-protein coupled receptor 3 family.
    产品使用声明
    销售限制 This product is not available for sale in Japan.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 50 µg

    merck millipore,默克密理博,AB9450,Anti-Metabotropic Glutamate Receptor 6 Antibody

上一件merck millipore产品：merck millipore,默克密理博,04-790,Anti-dimethyl-Histone H3 (Lys4) Antibody, clone AW30, rabbit monoclonal
下一件merck millipore产品：merck millipore,默克密理博,FCMAB288A6,Milli-Mark™ Anti-Ubiquitin Antibody, Lys63-Specific-Alexa Fluor647, clone Apu3


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