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merck millipore,默克密理博,FCMAB260PE,Milli-Mark™ Anti-Notch 1-PE Antibody, clone mN1A
产品名称：Milli-Mark™ Anti-Notch 1-PE Antibody, clone mN1A
产品型号：FCMAB260PE
Milli-Mark Anti-Notch 1-PE Antibody, clone mN1A detects level of Notch 1 & has been published & validated for use in FC.
merck millipore,默克密理博,FCMAB260PE,Milli-Mark™ Anti-Notch 1-PE Antibody, clone mN1A
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M FC M Phycoerythrin Monoclonal Antibody 描述 产品目录编号 FCMAB260PE 商名 - Milli-Mark
描述 Milli-Mark™ Anti-Notch 1-PE Antibody, clone mN1A 背景信息 The notch gene belongs to a family of epidermal growth factor (EGF) like homeotic genes, which encode transmembrane proteins with a variable number of cysteine-rich EGF-like repeats in the extracellular region. Four notch genes have been described in mammals, which include notch-1. notch-2, notch-3, and notch-4(Int-3), which have been implicated in the differentiation of the nervous system and other structures. The EGF-like proteins Delta and Serrate have been identified as ligands of notch-1. Mature notch proteins are heterodimeric receptors derived from the cleavage of notch pre-proteins into an extracellular subunit (NEC) containing multiple EGF-like repeats and a transmembrane subunit including intracellular region (Ntm). 产品信息 格式 Phycoerythrin 控制 - Mouse Thymocytes
演示 Purified mouse monoclonal IgG1 conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Milli-Mark Anti-Notch 1-PE Antibody, clone mN1A detects level of Notch 1 & has been published & validated for use in FC. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Cdc10-NCR region of mouse Notch1 expressed as a GST fusion protein. 表位 intracellular domain 克隆 clone mN1A 宿主 Mouse 特异性 Antibody recognizes Notch1 at the intracellular domain 同种型 IgG1 品种反应性 Mouse Species Reactivity Note Tested and passed on Mouse. Unconjugated Part No. MAB5352 is known to react with Rat and Feline. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_060087
基因符号 - TAN1
- NOTCH1
- notch1
- hN1
纯化方法 Protein G Purified UniProt编号 - P46531
UniProt汇总 FUNCTION: SwissProt: P46531 # Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. May be important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, may function as a receptor for neuronal DNER and may be involved in the differentiation of Bergmann glia (By similarity).
SIZE: 2556 amino acids; 272500 Da
SUBUNIT: Heterodimer of a C-terminal fragment N(TM) and an N- terminal fragment N(EC) which are probably linked by disulfide bonds. Interacts with DNER, DTX1, DTX2 and RBPSUH. Also interacts with MAML1, MAML2 and MAML3 which act as transcriptional coactivators for NOTCH1.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein (By similarity). & Notch 1 intracellular domain: Nucleus (By similarity). Note=Following proteolytical processing NICD is translocated to the nucleus (By similarity).
TISSUE SPECIFICITY: In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
PTM: Synthesized in the endoplasmic reticulum as an inactive form which is proteolytically cleaved by a furin-like convertase in the trans-Golgi network before it reaches the plasma membrane to yield an active, ligand-accessible form. Cleavage results in a C- terminal fragment N(TM) and a N-terminal fragment N(EC). Following ligand binding, it is cleaved by TNF-alpha converting enzyme (TACE) to yield a membrane-associated intermediate fragment called notch extracellular truncation (NEXT). This fragment is then cleaved by presenilin dependent gamma-secretase to release a notch-derived peptide containing the intracellular domain (NICD) from the membrane (By similarity). & Phosphorylated (By similarity).
DISEASE: SwissProt: P46531 # NOTCH1 truncation is associated with T-cell acute lymphoblastic leukemia. & Defects in NOTCH1 are a cause of aortic valve disease [MIM:109730]. The disorder consists of an early developmental defect in the aortic valve and a later de-repression of calcium deposition that causes progressive aortic valve disease. Calcification of the aortic valve is the third leading cause of heart disease in adults. The incidence increases with age, and it is often associated with a bicuspid aortic valve present in 1-2% of the population.
SIMILARITY: SwissProt: P46531 ## Belongs to the NOTCH family. & Contains 5 ANK repeats. & Contains 36 EGF-like domains. & Contains 3 LNR (Lin/Notch) repeats.产品使用声明 质量保证 Evaluated by flow cytometry using Mouse Thymocytes 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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