merck millipore,默克密理愽
  • merck millipore,默克密理博,CC077,Human Collagen Type V

  • merck millipore,默克密理博,CC077,Human Collagen Type V

    产品名称：Human Collagen Type V
    产品型号：CC077


    merck millipore,默克密理博,CC077,Human Collagen Type V

  • 产品介绍
  • merck millipore,默克密理博,CC077,Human Collagen Type V

    重要规格表

    主要应用
    CULT
    描述
    产品目录编号 CC077
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Human Collagen Type V
    概述 PROPERTIES:

    Molecular composition: [alpha1(V)]2 alpha2(V), native triple helix.

    Purity and retention of native helical structure was monitored by SDS-PAGE, ORD measurement, and by reaction with anti-collagen type-specific monoclonal antibodies.
    产品信息
    演示 Liquid, in 0.1M acetic acid, pH 3.0. No preservatives added.
    应用
    主要应用
    • Cell Culture
    生物信息
    浓缩 1 mg/ml
    纯度 95% by SDS-PAGE

    Contaminants: <2% collagen type I, <1% collagen type III, <2% collagen type IV and <0.5% non-collagen proteins.

    PURIFICATION:

    Purified by serial salt precipitations of a pepsin extraction of human fetal membranes and chromatography on DEAE-cellulose.
    来源 Human placenta, negative for HBsAG and HIV antibodies.
    品种 Human
    Entrez基因编号
    • NM_000093.3
    Entrez基因汇总 This gene encodes an alpha chain for one of the low abundance fibrillar collagens. Fibrillar collagen molecules are trimers that can be composed of one or more types of alpha chains. Type V collagen is found in tissues containing type I collagen and appears to regulate the assembly of heterotypic fibers composed of both type I and type V collagen. This gene product is closely related to type XI collagen and it is possible that the collagen chains of types V and XI constitute a single collagen type with tissue-specific chain combinations. Mutations in this gene are associated with Ehlers-Danlos syndrome, types I and II.
    基因符号
    • OTTHUMP00000064637
    • COL5A1
    UniProt编号
    • P20908
    UniProt汇总 FUNCTION: SwissProt: P20908 # Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin.
    SIZE: 1838 amino acids; 183560 Da
    SUBUNIT: Trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Interacts with CSPG4.
    SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix (By similarity).
    PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. & Sulfated on 40% of tyrosines.
    DISEASE: SwissProt: P20908 # Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type I (EDS-I) [MIM:130000]; also known as Ehlers-Danlos syndrome gravis. EDS-I is a connective-tissue disorder characterized by loose-jointedness and fragile, velvety, stretchable, bruisable skin that heals with peculiar 'cigarette-paper' scars. Inheritance is autosomal dominant. & Defects in COL5A1 are a cause of Ehlers-Danlos syndrome type II (EDS-II) [MIM:130010]; also known as Ehlers-Danlos syndrome mitis. Inheritance is autosomal dominant.
    SIMILARITY: SwissProt: P20908 ## Belongs to the fibrillar collagen family. & Contains 1 laminin G-like domain. & Contains 1 TSP N-terminal (TSPN) domain.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months. Do not thaw and refreeze.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,CC077,Human Collagen Type V

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