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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, FC, WB M Purified Monoclonal Antibody 描述 产品目录编号 CBL168 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-CD36 Antibody, clone SM-phi Alternate Names - Platelet Glycoprotein IV
产品信息 格式 Purified 演示 The monoclonal was purified by affinity chromatography and gel filtration and is presented in phosphate buffered saline containing 10mM sodium azide and 1mg/ml bovine serum albumin. We recommend that each laboratory determine an optimum working titre for use in its particular application. 应用 应用 Anti-CD36 Antibody, clone SM-phi is an antibody against CD36 for use in FC, WB, IH. 主要应用 - Immunohistochemistry
- Flow Cytometry
- Western Blotting
应用说明 Studies of platelet and monocyte receptor for thrombospondin
Studies of platelet collagen adhesion receptor
Flow cytometry
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Human tonsil cells and peripheral blood mononuclear cells 克隆 SM-phi 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody recognizes the 90 kDa single chain membrane glycoprotein (GPIIIb) that is found on monocytes/macrophages and platelets.
FUSION PARTNER: NS1 myeloma cell line同种型 IgM 品种反应性 Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NM_001001548.1
- NM_000072.2
- NM_001001547.1
Entrez基因汇总 The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Three alternatively spliced transcript variants encoding the same protein isoform have been found for this gene. 基因符号 - GPIIIB
- CD36
- PAS-4
- GPIV
- FAT
- CHDS7
- GP3B
- SCARB3
- PASIV
- GP4
UniProt编号 - P16671
UniProt汇总 FUNCTION: SwissProt: P16671 # Seems to have numerous potential physiological functions. Binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport.
SIZE: 472 amino acids; 53053 Da
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
PTM: N-glycosylated and O-glycosylated with a ratio of 2:1.
DISEASE: SwissProt: P16671 # Defects in CD36 are the cause of platelet glycoprotein IV deficiency [MIM:608404]; also known as CD36 deficiency. Platelet glycoprotein IV deficiency can be divided into 2 subgroups. The type I phenotype is characterized by platelets and monocytes/macrophages exhibiting complete CD36 deficiency. The type II phenotype lacks the surface expression of CD36 in platelets, but expression in monocytes/macrophages is near normal. & Genetic variations in CD36 are associated with susceptibility to coronary heart disease type 7 (CHDS7) [MIM:610938].
SIMILARITY: SwissProt: P16671 ## Belongs to the CD36 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 For use within 1 month of purchase store at +4°C, for long term storage aliquot antibody into small volumes and store at -20°C. 包装信息 数量 100 assays
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