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描述 产品目录编号 AG374 品牌系列 Chemicon®
商名 - Chemicon
描述 Metabotropic Glutamate Receptor 5, control peptide for AB5675 概述 Metabotropic Glutamate Receptor 5 (mGluR5) control peptide. Alternate Names - mGluR5
产品信息 演示 Liquid. 应用 主要应用 - Cell Function Assay
应用说明 Antibody blocking (AB5675)
Optimal working concentration must be determined by the end user.生物信息 浓缩 1 mg/mL 品种 Rat Entrez基因编号 - NM_000842.1
Entrez基因汇总 L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined. 基因符号 - GPRC1E
- GRM5
- mGluR5
- MGLUR5A
- mGlu5
- MGLUR5
- MGLUR5B
UniProt编号 - P41594
UniProt汇总 FUNCTION: SwissProt: P41594 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol- calcium second messenger system and generates a calcium-activated chloride current.
SIZE: 1212 amino acids; 132469 Da
SUBUNIT: The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and GRASP (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P41594 ## Belongs to the G-protein coupled receptor 3 family.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Store at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µg
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