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品种反应性 主要应用 宿主 格式 抗体类型 H, R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT39 描述 Anti-MFAP-2 (MAGP) Antibody Alternate Names - MAGP-1
- Microfibrillar-associated protein 2
- Microfibril-associated glycoprotein 1
- MAGP
背景信息 Along with elastin, elaunin, oxytalan, and elastin-associated proteins fibrillin-1, microfibrillar-associated glycoprotein-1 (MAGP or MFAP-2) can be found within the juxtacanalicular tissue of the inner and outer walls and within the collector channel walls of human eyes perfused at low and high pressure, among other certain human tissues. MAGP-1 (MFAP-2) is shown to play a significant role in the support and distensibility of the juxtacanalicular region of these collector channels. It is also reported to inhibit LTB-1 binding to fibrillin-1, stimulate the phosphorylation of Smad2, and thereby mediate the subsequent extracellular deposition of latent TGFbeta. 产品信息 格式 Affinity Purified 控制 - Human kidney tissue lysate.
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-MFAP-2 (MAGP) Antibody is an antibody against MFAP-2 (MAGP) for use in IH(P) & WB. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution of a previous lot detected MFAP-2 in rat supportive connective tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human MFAP-2 (MAGP). 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 HumanRat Species Reactivity Note Demonstrated to react with Rat and Human.
Other homologies: Mouse (82% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001128720
Entrez基因汇总 Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. 基因符号 - MAGP1
- MFAP2
纯化方法 Affinity Purified UniProt编号 - P55001
UniProt汇总 FUNCTION: Component of the elastin-associated microfibrils.
SUBUNIT STRUCTURE: Forms a ternary complex with BGN and ELN.
SUBCELLULAR LOCATION: Secreted > extracellular space > extracellular matrix.产品使用声明 质量保证 Evaluated by Western Blot in human kidney tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected MFAP-2 in human kidney tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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