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merck millipore,默克密理博,ABT340,Anti-AES Antibody
产品名称：Anti-AES Antibody
产品型号：ABT340
Anti-AES Antibody is a highly specific rabbit polyclonal antibody, that targets Amino-terminal enhancer of split & has been tested in western blotting, ICC & Immunofluorescence.
merck millipore,默克密理博,ABT340,Anti-AES Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB, ICC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT340 描述 Anti-AES Antibody Alternate Names - Protein GRG
- Amino-terminal enhancer of split
- GRG
- ESP1
- TLE5
- Gp130-associated protein GAM
- Protein ESP1
背景信息 Amino-terminal enhancer of split (AES), also known as GRG or ESP1 or TLE5 or Gp130-associated protein GAM, is a member of the Groucho/ transducin-like enhancer of split (TLE) family. AES belongs to a group of transcriptional co-repressors that play an important role in neurogenesis, segmentation and sex determination. AES is suggested to be a dominant repressor towards other family members of the TLE family and might be required for the initiation and maintenance of the differentiated state. AES has been shown to inhibit the NF-kappa-B-regulated gene expression. AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1). Recent studies suggest that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family. The apoptosis of cells transfected with AES and Bit1 implies that the Bit1-AES pathway contributing to anoikis is regulated by integrins, and more specifically – with the Alpha5Beta1 integrin. AES is found predominantly in muscle, heart and placenta. Additionally, in fetal tissues, AES is expressed highly in the heart, lung, kidney, brain and liver. 产品信息 格式 Affinity Purified 控制 - HEK293 cell lysate
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-AES Antibody is a highly specific rabbit polyclonal antibody, that targets Amino-terminal enhancer of split & has been tested in western blotting, ICC & Immunofluorescence. 主要应用 - Western Blotting
- Immunocytochemistry
应用说明 Immunocytochemistry Analysis: 10 µg/mL from a representative lot detected AES in HeLa cells.
Immunofluorescence Analysis: 20 µg/mL from a representative lot detected AES in HeLa cells.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the C-terminus of human AES. 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the C-terminus of AES. 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - AES
纯化方法 Antigen Affinity purified UniProt编号 - Q08117
产品使用声明 质量保证 Evaluated by Western Blotting in HEK293 cell lysate.
Western Blotting Analysis: 1 µg/mL of this antibody detected AES in 15 µg of HEK293 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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