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品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT332 描述 Anti-ZEB2 Antibody Alternate Names - Smad interacting-protein 1
- Zinc finger E-box binding homeobox 2
背景信息 Zinc finger E-box-binding homeobox 2 (ZEB2), also known as Smad-interacting protein 1 (SIP1, SMADIP1) and Zinc finger homeobox protein 1b (ZFHX1B, ZFX1B), is a transcriptional inhibitor that binds to DNA sequence 5'-CACCT-3' in different promoters and interacts with activated SMADs. ZEB2 has been shown to repress the transcription of the E-cadherin gene and induce epithelial-mesenchymal transition, a genetic program controlling cell migration during embryonic development and wound healing in vitro. It is suggested that ZEB2 contributes to tumor progression since it’s been demonstrated to protect cells from DNA damage-induced apoptosis. Recent studies have shown that ZEB2 is often observed in the cytoplasm in numerous cancer tissues, implying that its localization may be regulated in normal and tumor tissues. Mutations in this gene are also associated with Mowat-Wilson syndrome (MWIS), also known as Hirschsprung disease-mental syndrome. 产品信息 格式 Affinity Purified 控制 - Jurkat cell lysate
演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Detect ZEB2 using this rabbit polyclonal antibody, Anti-ZEB2 Antibody validated for use in western blotting, ICC & Immunofluorescence. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected ZEB2 in Jurkat cells.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected ZEB2 in Jurkat cells.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human ZEB2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - ZFX1B
- ZEB2
- ZFHX1B
- SMADIP1
- SIP1
- SIP-1
纯化方法 Antigen Affinity purified UniProt编号 - O60315
产品使用声明 质量保证 Evaluated by Western Blotting in Jurkat cell lysate.
Western Blotting Analysis: 2 µg/mL of this antibody detected ZEB2 in 15 µg of Jurkat cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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