merck millipore,默克密理博,ABT291,Anti-DOCK3 Antibody

搜索"Merck Millipore 密理愽"产品

Merck Millipore 默克密理愽

当前位置：首页 > >Merck Millipore > 生命科学研究
生命科学研究

merck millipore,默克密理博,ABT291,Anti-DOCK3 Antibody
产品名称：Anti-DOCK3 Antibody
产品型号：ABT291
Anti-DOCK3 detects levels of DOCK3 proteins & has been published & validated for use in WB, IHC & ICC.

merck millipore,默克密理博,ABT291,Anti-DOCK3 Antibody

产品介绍

merck millipore,默克密理博,ABT291,Anti-DOCK3 Antibody

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	ICC, WB, IHC	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABT291
描述	Anti-DOCK3 Antibody
Alternate Names	Presenilin binding protein Modifier of cell adhesion dedicator of cytokinesis 3
背景信息	Dedicator of cytokinesis3 (DOCK3) is a potential guanine nucleotide exchange factor (GEF) which activates GTPases by exchanging bound GDP for free GTP. DOCK3 is associated in Alzheimer disease tangles and regulates the accumulation of amyloid precursor protein and beta-amyloid. Overexpression of DOCK3 in neural cells promotes axonal outgrowth downstream of brain-derived neurotrophic factor (BDNF) signaling. DOCK3 binds to and inactivates glycogen synthase kinase-3β (GSK-3β) at the plasma membrane, thereby promoting axon branching and microtubule assembly. By stimulating actin polymerization and microtubule assembly, DOCK3 plays important roles downstream of BDNF signaling in the CNS.

产品信息
格式	Affinity Purified
控制	Human brain tissue lysate
演示	Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide and 50% glycerol.

应用
应用	Anti-DOCK3 detects levels of DOCK3 proteins & has been published & validated for use in WB, IHC & ICC.
主要应用	Immunocytochemistry Western Blotting Immunohistochemistry
应用说明	Immunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected DOCK3 in normal human brain and Alzheimer's brain tissues. Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected DOCK3 in A431 and HeLa cells.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to human DOCK3.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
品种反应性	Human
Species Reactivity Note	Demonstrated to react with Human.
抗体类型	Polyclonal Antibody
基因符号	MOCA DOCK3
纯化方法	Antigen Affinity purified
UniProt编号	Q8IZD9

产品使用声明
质量保证	Evaluated by Western Blotting in human brain tissue lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected DOCK3 in 10 µg of human brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.