- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 B, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT154 描述 Anti-Cerberus Antibody Alternate Names - DAN domain family member 4
- Cerberus
- Cerberus-related protein
背景信息 The cerberus protein is expressed in the anterior region of the gastrula and is a member of the cysteine superfamily. Studies show cerberus induces differentiation of structural components in the head during embryonic development. Data also shows that a segmental pattern of cerberus is also observed in nascent and newly formed somites suggesting an additional role in development of the axial skeleton, musculature, and peripheral nervous systems. Cerberus is secreted in the surrounding extracellular space and functions by inhibiting signaling molecules. Research indicates the neural-inducing and mesoderm-inhibiting activities of cerberus results from the specific binding of cerberus to BMP and Nodal molecules. Cerberus can bind directly to BMPs and inhibit their activities. 产品信息 格式 Affinity Purified 控制 - Saos-2 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Cerberus Antibody detects level of Cerberus & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Cerberus. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 BovineHuman Species Reactivity Note Demonstrated to react with Human.
Predicted to react with Bovine based on 100% sequence homology. Other homologies: Mouse and Rat (77% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_005445
Entrez基因汇总 This gene encodes a cytokine member of the cysteine knot superfamily, characterized by nine conserved cysteines and a cysteine knot region. The cerberus-related cytokines, together with Dan and DRM/Gremlin, represent a group of bone morphogenetic protein (BMP) antagonists that can bind directly to BMPs and inhibit their activity. [provided by RefSeq, Jul 2008]. 基因符号 - DAND4
- CER1
纯化方法 Affinity Purified UniProt编号 - O95813
UniProt汇总 FUNCTION: Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak (By similarity).
SUBUNIT STRUCTURE: Forms monomers and predominantly dimers (By similarity).
SUBCELLULAR LOCATION: Secreted Probable.
PTM: N-glycosylated (By similarity).
SEQUENCE SIMILARITIES: Belongs to the DAN family.
Contains 1 CTCK (C-terminal cystine knot-like) domain.
SEQUENCE CAUTION: The sequence AAH69503.1 differs from that shown. Reason: Erroneous termination at position 266. Translated as Ser.产品使用声明 质量保证 Evaluated by Western Blot in Saos-2 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Cerberus in 10 µg of Saos-2 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,AB3704,Anti-Orexin-A Antibody
下一件merck millipore产品：merck millipore,默克密理博,AB928,Anti-Follicle Stimulating Hormone Antibody
相关产品
merck millipore,默克密理博,573125,STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem
merck millipore,默克密理博,341599,FGF-10, Human, Recombinant
merck millipore,默克密理博,14-758M,Ret (V804L) Protein, active, 250 µg
merck millipore,默克密理博,09-893,Anti-BAF (BANF1) Antibody
merck millipore,默克密理博,AB3704,Anti-Orexin-A Antibody
merck millipore,默克密理博,AB928,Anti-Follicle Stimulating Hormone Antibody
merck millipore,默克密理博,20-175,HDAC Assay Buffer, 5X
merck millipore,默克密理博,SF-895,ALK; Human, Cyanine 5, RNA Detection Probe,SmartFlare
merck millipore,默克密理博,NS230,Neurite Outgrowth Assay Plus Kit (3 µm)
