merck millipore,默克密理愽
  • merck millipore,默克密理博,573125,STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem

  • merck millipore,默克密理博,573125,STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem

    产品名称：STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem
    产品型号：573125
    The STAT3 Inhibitor IX, Cpd188, also referenced under CAS 823828-18-8, controls the biological activity of STAT3.

    merck millipore,默克密理博,573125,STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,573125,STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem

    重要规格表

    经验配方 CAS号
    C₁₉H₁₅NO₇S₂823828-18-8
    描述
    概述 A cell-permeable naphthol compound that inhibits IL-6-stimulated STAT3 Tyr705 phosphorylation and nuclear translocation in HepG2 cells (IC50 = 73 and 39 µM, respectively) by targeting STAT3 SH2 domain peptide-binding pocket (IC50 = 20 µM against EGFR-derived pY-peptide binding), while exhibiting little effect against IFN-γ-stimulated HepG2 cellular STAT1 phosphorylation even at concentrations as high as 300 µM. Shown to preferentially induce apoptosis in cultures expressing constitutively active STAT3 (EC50 = 0.73, 3.96, and 7.01 µM in MDA-MB-468, MDA-MB-231, and MDA-MB-435 cultures, respectively), while being less effective against cells without constitutively active STAT3 (EC50 = 15.5 and 17.19 µM in MDA-MB-453 and MCF7 cultures, respectively).
    产品目录编号 573125
    品牌系列 Calbiochem®
    同义词 4-((3-(Carboxymethylsulfanyl)-4-hydroxy-1-naphthyl)sulfamoyl)benzoic acid
    参考
    参考 Xu, X., et al. 2009. PLoS One 4, e4783.
    产品信息
    CAS号 823828-18-8
    形式 Beige solid
    Hill配方 C₁₉H₁₅NO₇S₂
    化学配方 C₁₉H₁₅NO₇S₂
    Molar Mass 433.5
    结构配方图像
    生物信息
    纯度 ≥95% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Ambient Temperature Only
    毒性 Standard Handling
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,573125,STAT3 Inhibitor IX, Cpd188 - CAS 823828-18-8 - Calbiochem

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