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品种反应性 主要应用 宿主 格式 抗体类型 M, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABT106 描述 Anti-Tric-A Antibody Alternate Names - Transmembrane protein 38A
- Trimeric intracellular cation channel type A
- TRIC-A
- TRICA
- 27 kDa sarcoplasmic reticulum protein
- Mitsugumin-33A
- SPR-27
背景信息 TRIC-A (Trimeric intracellular cation channel type A) is one of two TRIC (trimeric intracellular cation) Ca2+ counter-ion channels located on the sarcoplasmic/endoplasmic reticulum membrane. TRIC-A contains three trans-membrane peptides and forms homo-trimers that are bullet-shaped. TRIC-A is a cation-selective channel that seems to be controlled by the trans-membrane voltage. TRIC-A stabilizes Ca2+ levels and loss of TRIC-A could lead to a Ca2+ overload and cause cardiac muscle failure. 产品信息 格式 Affinity Purified 控制 - Human heart tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect Tric-A using this Anti-Tric-A Antibody validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse Tric-A. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human.
Predicted to react with Mouse based on immunogen design.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_653117
基因符号 - Tmem38a
纯化方法 Affinity Purified UniProt编号 - Q3TMP8
UniProt汇总 FUNCTION: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores.
SUBUNIT STRUCTURE: Homotrimer (by similarity).
SUBCELLULAR LOCATION: Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus membrane (by similarity).
TISSUE SPECIFICITY: Expressed at high levels in heart and striated muscle. Also detected in brain, lung and kidney.
DOMAIN: The second transmembrane domain has been proposed to cross only half of the lipid bilayer and to loop back into the cytosol, so that the domains on each side of this domain are both found on the cytosolic face of the membrane. The cytosolic loop may form an ion-conducting pore.
DISRUPTION PHENOTYPE: Mice are viable. Mice lacking Tmem38a and Tmem38b show a weak heartbeat at E9.5 followed by loss of cardiomyocyte viability and embryonic lethality around E10.5.
SEQUENCE SIMILARITIES: Belongs to the TMEM38 family.产品使用声明 质量保证 Evaluated by Western Blot in human heart tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Tric-A in 10 µg of human heart tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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