- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABS983 描述 Anti-DMT1 Antibody Alternate Names - DMT-1
- NRAM1
- NRAMP 2
- NRAMP-2
- Divalent metal transporter 1
- Divalent cation transporter 1
背景信息 Divalent metal ion transporter 1 (DMT1) is a proton-coupled Fe2+ transporter that is essential for iron uptake in enterocytes and for transferrin-associated endosomal iron transport in many other cell types. DMT1 dysfunction is associated with several diseases such as iron overload disorders and neurodegenerative diseases. DMT1 can transport manganese, cobalt, cadmium, nickel, and vanadium. DMT1 is also involved in iron transport from acidified endosomes into the cytoplasm in erythroid precursor cells as well as liver internal metabolism of iron. Interestingly too, in mammalian cells, mitochondria receive most incoming iron, and the outer mitochondrial membrane appears to be a major location for DMT1, which appears to be the major importer of iron into the mitochondria. 产品信息 格式 Serum 演示 Rabbit polyclonal serum with 0.05% sodium azide. 应用 应用 This Anti-DMT1 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of DMT1. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Western Blot Analysis: 2 µg/ml of this antibody detected DMT1 in 50 µg of mouse liver, spleen and duodenum tissue lysate (Schumann, K.,et al. (2010). Journal of Trace Elements in Medicine and Biology 24 (2010) 58–66)
Immunocytochemistry Analysis: A 1:100 dilution of this antibody from a representative lot detected DMT1 in Hela, A431, and N1H-3T3 cells生物信息 免疫原品种 Recombinant protein corresponding to human DMT1. 浓缩 Please refer to lot specific datasheet. 宿主 Rabbit 品种反应性 MouseHuman Species Reactivity Note Human, Mouse. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000608
基因符号 - NRAMP2
- SLC11A2
- DCT1
- DMT1
纯化方法 Unpurified UniProt编号 - P49281
产品使用声明 质量保证 Evaluated by Western Blotting in human placenta tissue lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected DMT1 in 10 µg of human placenta tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
上一件merck millipore产品：merck millipore,默克密理博,2210,Cell Proliferation Assay Kit, WST dye; ELISA based
下一件merck millipore产品：merck millipore,默克密理博,539158,20S Proteasome Assay Kit, SDS-Activated
相关产品
merck millipore,默克密理博,650357,Trypsin Inhibitor, Soybean, High Activity - CAS 9035-81-8 - Calbiochem
merck millipore,默克密理博,12-346,Acetyl-Histone H4 (Lys16) Peptide
merck millipore,默克密理博,MAB858-4,Anti-RSV Antibody, blend, clones 133-1H, 131-2G, and 130-12H
merck millipore,默克密理博,2210,Cell Proliferation Assay Kit, WST dye; ELISA based
merck millipore,默克密理博,539158,20S Proteasome Assay Kit, SDS-Activated
merck millipore,默克密理博,PIHT12R48,Millicell 悬挂式细胞培养皿, PET, 0.4 µm
merck millipore,默克密理博,07-1481,Anti-IRAK-M Antibody, a.a. 581-596
merck millipore,默克密理博,422690,c-Kit, Cytoplasmic Domain, His•Tag, Human, Recombinant, S. frugiperda
merck millipore,默克密理博,OP76,Anti-p21WAF1 (Ab-4) Mouse mAb (65)