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merck millipore,默克密理博,05-1059,Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal
产品名称：Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal
产品型号：05-1059
Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8 detects level of phospho-p38α(Thr180/Tyr182) & has been published & validated for use in WB & IF.
merck millipore,默克密理博,05-1059,Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal
- 产品介绍
- merck millipore,默克密理博,05-1059,Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Vrt, H, M WB Rb Culture Supernatant Monoclonal Antibody 描述 产品目录编号 05-1059 描述 Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8, rabbit monoclonal Alternate Names - stress-activated protein kinase 2A
- CSAID-binding protein
- Csaids binding protein
- Cytokine suppressive anti-inflammatory drug-binding protein
- MAP kinase MXI2
- MAP kinase p38 alpha
- MAX-interacting protein 2
- Mitogen-activated protein kinase p38 alpha
- cytokine suppressive anti-inflammatory drug binding protein
- mitogen-activated protein kinase 14
- p38 MAP kinase
- p38 mitogen activated protein kinase
- p38alpha Exip
背景信息 The p38 family refers to the SAPK2/3 Kinases (Stess-Activated Protein Kinases), a subfamily of JNK/SAPK family. p38/SAPK Kinases are also activated by stresses, most notably inflammatory cytokines, irradiation, and certain toxins such as anisomycin and arsenite. SAPKs have been implicated in many pathological conditions, including inflammation, cancer and neurodegenerative diseases. As with the other MAPK family members (ERK, JNK, p38MAPK, and ERK5), p38 is activated through phosphorylation on both threonine and tyrosine residues at the Thr-X-Tyr dual phosphorylation motif, where X is Gly for p38. Once phosphorylated and active, it then goes on to phosphorylate downstream targets in both the cytoplasm and the nucleus. Some of their main targets of p38 are the kinase MAPKAPK2 and the transcription factor ATF2 that are activated via their phosphorylation. 产品信息 格式 Culture Supernatant 演示 Rabbit monoclonal antibody in culture supernatant containing 0.05% sodium azide. 应用 应用 Anti-phospho-p38α(Thr180/Tyr182) Antibody, clone 8.78.8 detects level of phospho-p38α(Thr180/Tyr182) & has been published & validated for use in WB & IF. 主要应用 - Western Blotting
生物信息 免疫原品种 Synthetic peptide corresponding to amino acids surrounding and including phosphorylated Thr180/Tyr182 of human p38α. 表位 Phosphorylated Thr180/Tyr182 克隆 8.78.8 宿主 Rabbit 特异性 This antibody detects p38α when phosphorylated on Thr180/Tyr182. 同种型 IgG 品种反应性 VertebratesHumanMouse Species Reactivity Note Human and Mouse tested. Predicted to cross-react with many other species based on 100% sequence homology with immunogen. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_001306
Entrez基因汇总 The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq] 基因符号 - p38b
- P38B
- P38BETA2
- PRKM11
- SAPK2
- SAPK2B
- p38-2
- p38Beta
修改 - Phosphorylation
UniProt编号 - Q15759
UniProt汇总 FUNCTION: Kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress. Phosphorylates preferentially transcription factor ATF2.
CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
COFACTOR: Magnesium By similarity.
ENZYME REGULATION: Activated by phosphorylation on threonine and tyrosine by MKK6. Inhibited by pyridinyl-imidazole related compounds.
TISSUE SPECIFICTY: Highest levels in the brain and heart. Also expressed in the placenta, lung, liver, skeletal muscle, kidney and pancreas.
DOMAIN: The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
PTM: Dually phosphorylated on Thr-180 and Tyr-182, which activates the enzyme Probable.
SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Contains 1 protein kinase domain.产品使用声明 质量保证 Evaluated by western blot on anisomycin-treated HeLa cell lysate.
Western Blot Analysis: 1:5,000-1:10,000 dilution of this antibody was used to detect p38 phosphorylated on Thr180/Tyr182 in anisomycin-treated HeLa and NIH/3T3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20ºC from date of receipt. 包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,650357,Trypsin Inhibitor, Soybean, High Activity - CAS 9035-81-8 - Calbiochem
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