merck millipore,默克密理愽
  • merck millipore,默克密理博,FCMAB120P,Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2

  • merck millipore,默克密理博,FCMAB120P,Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2

    产品名称：Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2
    产品型号：FCMAB120P
    This Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2 is validated for use in FC for the detection of Beta-catenin.

    merck millipore,默克密理博,FCMAB120P,Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2

  • 产品介绍
  • merck millipore,默克密理博,FCMAB120P,Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    MFCMPhycoerythrinMonoclonal Antibody
    描述
    产品目录编号 FCMAB120P
    商名
    • Milli-Mark
    描述 Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2
    Alternate Names
    • Beta Catenin <br />Catenin (cadherin-associated protein), beta 1
    背景信息 Catenins are proteins found in complexes with cadherin cell adhesion molecules of animal cells. The first two catenins that were identified became known as α-catenin and β-catenin. α-Catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. When β-catenin was sequenced it was found to be a member of the armadillo family of proteins. These proteins have multiple copies of the so-called armadillo repeat domain which is specialized for protein-protein binding. An increase in β-catenin production has been noted in those people who have Basal Cell Carcinoma and leads to the increase in proliferation of related tumors. When β-catenin is not associated with cadherins and α-catenin, it can interact with other proteins such as Catenin Beta Interacting Protein 1 (ICAT) and adenomatosis polyposis coli (APC). Recent evidence suggests that β-catenin plays an important role in various aspects of liver biology including liver development (both embryonic and postnatal), liver regeneration following partial hepatectomy, HGF-induced hepatomegaly, liver zonation, and pathogenesis of liver cancer.
    产品信息
    格式 Phycoerythrin
    控制
    • ATCC L-cells.
    演示 Purified mouse monoclonal IgG1κ conjugated to PE in PBS with 0.1% sodium azide and 15 mg/mL BSA.
    应用
    应用 This Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2 is validated for use in FC for the detection of Beta-catenin.
    主要应用
    • Flow Cytometry
    生物信息
    免疫原品种 Full length, GST-tagged recombinant beta catenin.
    克隆 7F7.2
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Mouse
    特异性 Antibody recognizes Beta-catenin.
    同种型 IgG1κ
    品种反应性 Mouse
    Species Reactivity Note Tested and passed on Mouse. Unconjugated Ab part number 04-958 also reacts against human and rat.
    抗体类型 Monoclonal Antibody
    Entrez基因编号
    • NP_001895
    Entrez基因汇总 Beta-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM]
    基因符号
    • DKFZp686D02253
    • CTNNB
    • CTNNB1
    • FLJ25606
    • FLJ37923
    纯化方法 Protein G purfied
    UniProt编号
    • P35222
    UniProt汇总 FUNCTION: Involved in the regulation of cell adhesion and in signal transduction through the Wnt pathway.

    SUBUNIT: Two separate pools are found in the cytoplasm: one is PSEN1/cadherin/catenin complex which anchors to the actin cytoskeleton. The other pool is part of a large complex containing AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. Wnt-dependent activation of DVL antagonizes the action of GSK3B. When GSK3B activity is inhibited the complex dissociates, CTNNB1 is dephosphorylated and is no longer targeted for destruction. The stabilized protein translocates to the nucleus, where it binds TCF/LEF-1 family members, TBP, BCL9 and possibly also RUVBL1 and DUPLIN. Binds CTNNBIP and EP300. CTNNB1 forms a ternary complex with LEF1 and EP300 that is disrupted by CTNNBIP1 binding (By similarity). Interacts with the PDZ domain of TAX1BP3; this interaction inhibits the transcriptional activity of CTNNB1 (By similarity). Interacts with AJAP1, BAIAP1, CARM1, CTNNA3, CXADR and PCDH11Y. Binds SLC9A3R1. Interacts with GLIS2 and MUC1. Interacts with SLC30A9. Interacts with XIRP1 (By similarity).

    SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Cytoplasm, cytoskeleton. Note=Cytoplasmic when it is unstabilized (high level of phosphorylation) or bound to CDH1. Translocates to the nucleus when it is stabilized (low level of phosphorylation). Interaction with GLIS2 and MUC1 promotes nuclear translocation.

    TISSUE SPECIFICITY: Expressed in several hair follicle cell types: basal and peripheral matrix cells, and cells of the outer and inner root sheats. Expressed in colon.
    产品使用声明
    质量保证 Evaluate by flow cytometry using ATCC L-cells.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
    包装信息
    数量 100 tests

    merck millipore,默克密理博,FCMAB120P,Milli-Mark Anti-Beta-catenin-PE Antibody, clone 7F7.2

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