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品种反应性 主要应用 宿主 格式 抗体类型 Rhesus Macaque, R, H, M, Po, Pm WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS55 描述 Anti-InsP3R Antibody, Type 1 Alternate Names - IP3 receptor isoform 1
- inositol 1,4,5-triphosphate receptor, type 1
- spinocerebellar ataxia 16
- inositol 1,4,5-trisphosphate receptor type 1
- Type 1 inositol 1,4,5-trisphosphate receptor
- Type 1 InsP3 receptor
- IP3 receptor
- spinocerebellar ataxia 15
背景信息 The inositol (1,4,5)-trisphosphate receptor (InsP3R) regulates calcium release from storage within cells and plays an important role in neuronal function. InsP3R has been linked to Huntington’s disease. InsP3R has also been linked to the association between cAMP and Ca2+ signaling in regions of the brain, including the neostriatum. 产品信息 格式 Affinity Purified 控制 - Rat brain microsomal tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 This Anti-InsP3R Antibody, Type 1 is validated for use in WB, IP, IH(P) for the detection of InsP3R. 主要应用 - Western Blotting
应用说明 Immunohistochemistry Analysis: 1:1500 dilution from a previous lot detected InsP3R in purkinje cells at the junction of the granular and molecular layers of normal rat cerebellum tissue.
Immunoprecipitation Analysis: 10 µg of Anti-InsP3R, Type 1 immunoprecipitated InsP3R, Type 1 from rat brain microsomal prep RIPA lysate.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the cytoplasmic domain of rat InsP3R. 表位 Cytoplasmic domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes InsP3R at the cytoplasmic domain. 品种反应性 Rhesus MacaqueRatHumanMousePigPrimate Species Reactivity Note Demonstrated to react with Human and Rat. Predicted to react with Mouse, Porcine, Primate, and Rhesus Macaque based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001007236
Entrez基因汇总 receptor for inositol 1,4,5-triphosphate; mediates a IP3-dependent calcium influx [RGD]. 基因符号 - SCA15
- ITPR1
- IP3R1
- Insp3r1
- InsP3R1
- IP3R
- INSP3R1
纯化方法 Affinity purified UniProt编号 - P29994
UniProt汇总 FUNCTION: Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5-trisphosphate.
SUBUNIT STRUCTURE: Homotetramer. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Interacts with CABP1. Interacts with AHCYL1 and MRVI1 (By similarity).
SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Multi-pass membrane protein.
TISSUE SPECIFICTY: Isoform 3 is found in the brain while isoform 7 is found in the fetal brain and peripheral tissues.
DOMAIN: The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.
PTM: Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels.
Phosphorylated on tyrosine residues (By similarity).
MISCELLANEOUS: Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium-binding protein which then inhibits the receptor.
SEQUENCE SIMILARITIES: Belongs to the InsP3 receptor family.
Contains 5 MIR domains.产品使用声明 质量保证 Evaluated by Western Blot in rat brain microsomal tissue lysate.
Western Blot Analysis: 0.1 µg/mL of this antibody detected InsP3R on 10 µg of rat brain microsomal tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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