merck millipore,默克密理愽
  • merck millipore,默克密理博,14-502M,Akt3/PKBγ (S472D) Protein, active, 250 µg

  • merck millipore,默克密理博,14-502M,Akt3/PKBγ (S472D) Protein, active, 250 µg

    产品名称：Akt3/PKBγ (S472D) Protein, active, 250 µg
    产品型号：14-502M
    Active, N-terminal His6-tagged, recombinant human Akt3/PKBγ, amino acids 117-end, containing a S472D mutation. For use in Kinase Assays.

    merck millipore,默克密理博,14-502M,Akt3/PKBγ (S472D) Protein, active, 250 µg

  • 产品介绍
  • merck millipore,默克密理博,14-502M,Akt3/PKBγ (S472D) Protein, active, 250 µg

    描述
    产品目录编号 14-502M
    品牌系列 Upstate
    商名
    • Upstate
    描述 Akt3/PKBγ (S472D) Protein, active, 250 µg
    概述 N-terminal His6-tagged, recombinant human Akt3/PKBγ, amino acids 117-end, containing a S472D mutation.
    应用
    应用 Active, N-terminal His6-tagged, recombinant human Akt3/PKBγ, amino acids 117-end, containing a S472D mutation. For use in Kinase Assays.
    主要应用
    • Kinase Assay
    生物信息
    来源 Human Akt3/PKBγ expressed in Sf21 cells
    品种 Human
    特异活性 For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
    Entrez基因编号
    • NM_181690.1
    • NM_005465.3
    Entrez基因汇总 The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described.
    基因符号
    • STK-2
    • AKT3
    • PRKBG
    • DKFZP434N0250
    • PKBG
    • RAC-gamma
    • RAC-PK-gamma
    蛋白靶 Akt3/PKBγ
    纯化方法 Ni2+/NTA-agarose
    靶子系列 AGC
    UniProt编号
    • Q9Y243
    UniProt汇总 FUNCTION: SwissProt: Q9Y243 # IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.
    SIZE: 479 amino acids; 55775 Da
    SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.
    TISSUE SPECIFICITY: In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney.
    DOMAIN:SwissProt: Q9Y243 Binding of the PH domain to the phosphatidylinositol 3- kinase alpha (PI(3)K) results in its targeting to the plasma membrane.
    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. & Contains 1 AGC-kinase C-terminal domain. & Contains 1 PH domain. & Contains 1 protein kinase domain.
    产品使用声明
    质量保证 routinely evaluated by phosphorylation of Crosstide
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 6 months at -70°C
    包装信息
    数量 250 µg
    包装 Also available in 10 μg size (cat#14-502) and in bulk (cat# 14-502-K).

    merck millipore,默克密理博,14-502M,Akt3/PKBγ (S472D) Protein, active, 250 µg

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