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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABS530 描述 Anti-CDC7 Antibody Alternate Names - huCdc7
- Cell division cycle 7-related protein kinase
- CDC7-related kinase
- HsCdc7
背景信息 CDC7, also known as CDC7-related kinase or HsCdc7/HuCdc7, and encoded by the gene CDC7/CDC7L1, is a critical kinase needed to phosphorylate critical substrates that regulate the G1/S phase transition and DNA replication. CDC7 is a serine-threonine kinase that forms a complex with either DBF4 or DBF4B proteins leading to the activation of the kinase activity necessary for its function. Additionally, CDC7 phosphorylates and forms a complex with MCM2 and MCM3 proteins which are highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. CDC7 is localized to the localized in the nucleus, and CDC7 is over expressed in many tumors and transformed cell lines. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-CDC7 Antibody detects level of CDC7 & has been published & validated for use in CDC7. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the protein kinase domain of human CDC7. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Demonstrated to react with Human. Predicted to react with Rhesus Macaque based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003494
基因符号 - CDC7L1
- CDC7
纯化方法 Affinity purified UniProt编号 - O00311
产品使用声明 质量保证 Evaluated by Western Blotting in human spleen tissue lysate.
Western Blotting Analysis: 1 μg/mL of this antibody detected CDC7 in 10μg of human spleen tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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