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品种反应性 主要应用 宿主 格式 抗体类型 R, H, M WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABS500 描述 Anti-CDT2 Antibody Alternate Names - Retinoic acid-regulated nuclear matrix-associated protein
- Denticleless protein homolog
- B1- and CUL4-associated factor 2
- Lethal(2) denticleless protein homolog
背景信息 CDT2, also known as DTL, Denticleless protein homolog, DDB1- and CUL4-associated factor 2, Lethal(2) denticleless protein homolog, or Retinoic acid-regulated nuclear matrix-associated protein, and encoded by the gene DTL/CDT2/CDW1/DCAF2/L2DTL/RAMP, is a component of the DCX(DTL) E3 ubiquitin ligase complex and is the substrate-specific adapter for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT2 is important because degradation of CDT1 in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDT2 is localized to the nucleus primarily but it translocates to the cytoplasm during mitosis. CDT2 is expressed in multiple tissues at varying degrees with high expression in adult placenta, testis, thymus, bone marrow and fetal all fetal tissues, and low expression in adult muscle, spleen and lymph node. 产品信息 格式 Serum 演示 Rabbit polyclonal serum containing 0.05% sodium azide. 应用 应用 Anti-CDT2 Antibody detects level of CDT2 & has been published & validated for use in CDT2. 主要应用 - Western Blotting
应用说明 Western Blotting Analysis: A representative lot from an independent laboratory detected CDT2 in transfected 293T cell lysates (Abbas, T., et al. (2013). Mol Cell. 49(6):1147-1158.). 生物信息 免疫原品种 Recombinant protein corresponding to human CDT2. 宿主 Rabbit 品种反应性 RatHumanMouse 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_001009297
基因符号 - RAMP
- DTL
- CDT2
- CDW1
- DCAF2
- L2DTL
纯化方法 Unpurified UniProt编号 - Q9NZJ0
产品使用声明 质量保证 Evaluated by Western Blotting in A431 cell lysate.
Western Blotting Analysis: A 1:1,000 dilution of this antibody detected CDT2 in 10 µg of A431 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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