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经验配方 CAS号 C₅₁H₃₄N₆O₂₃S₆ . 6Na 129-46-4 描述 概述 A reversible and competitive inhibitor of protein tyrosine phosphatases. An anti-neoplastic, anti-angiogenic agent that uncouples G-proteins from receptors presumably by blocking their interaction with intracellular receptor domains. Inhibits GDP-GTP exchange, the rate limiting step in the activation of Gα-subunits. A competitive inhibitor of reverse transcriptase. Reported to inhibit topoisomerases I and II. Inhibits Ca2+-ATPase in sarcoplasmic reticulum membranes. Also inhibits the cell-surface binding of various growth factors, including EGF, PDGF, and TGF-β. An inhibitor of phospholipase D (IC50 = 15 µM). Reported to interact with ATP-binding enzymes and P2-purinergic receptors. An effective inhibitor of angiogenesis in the calmodulin assay when given in combination with angiostatic steroids. 产品目录编号 574625 品牌系列 Calbiochem®
同义词 PTP Inhibitor VI, P2Y Antagonist I, Purinergic Receptor P2Y Antagonist I 参考 参考 Meyers, M.O., et al. 2000. J. Surg. Res. 91, 130.
Hohenegger, M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 346.
Waldhoer, M., et al. 1998. Mol. Pharmacol. 53, 808.
Zhang, Y.L., et al. 1998. J. Biol. Chem. 273, 12281.
Hohenegger, M., et al. 1996. Mol. Pharmacol. 50, 1443.
Emmick, J.J., et al. 1994. J. Pharmacol. Exp. Ther. 269, 717.
Denhertog, A., et al. 1992. J. Physiol. 454, 591.
Nakajima, M., et al. 1991. J. Biol. Chem. 266, 9661.
Wilks, J.W., et al. 1991. Int. J. Radiat. Biol. 60, 73.
Huang, R.C., et al. 1990. Mol. Pharmacol. 37, 304.
Kopp, R. and Pfeiffer, A. 1990. Cancer Res. 50, 6490.产品信息 CAS号 129-46-4 具有ATP竞争性 N 形式 White crystalline solid Hill配方 C₅₁H₃₄N₆O₂₃S₆ . 6Na 化学配方 C₅₁H₃₄N₆O₂₃S₆ . 6Na Molar Mass 1429.2 吸湿 Hygroscopic
可逆 Y 结构配方图像 生物信息 主靶 protein tyrosine phosphatases 主靶IC50 15 µM against phospholipase D 纯度 ≥98% by HPLC 理化信息 细胞可渗透 N 溶解度 H₂O GHS安全信息 RTECS QM7000000 储存和货运信息 货运代码 Ambient Temperature Only
毒性 Standard Handling
储存 +2°C to +8°C
吸湿 Hygroscopic
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
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