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  • merck millipore,默克密理博,ABS157,Anti-SKAR Antibody

  • merck millipore,默克密理博,ABS157,Anti-SKAR Antibody

    产品名称：Anti-SKAR Antibody
    产品型号：ABS157
    Anti-SKAR Antibody detects level of SKAR & has been published & validated for use in Western Blotting, ICC.

    merck millipore,默克密理博,ABS157,Anti-SKAR Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABS157,Anti-SKAR Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, HICC, WBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABS157
    描述 Anti-SKAR Antibody
    Alternate Names
    • SKAR
    • Polymerase delta-interacting protein 3
    • 46 kDa DNA polymerase delta interaction protein
    • p46
    • S6K1 Aly/REF-like target
    背景信息 SKAR (S6K1 Aly/REF-like substrate) is a nuclear protein that is localized at exon junction complexes (EJC) which interact with pre-mRNA molecules to ensure that correct splicing has occurred. SKAR recruits ribosomal protein S6 kinase 1 (S6K1) to EJCs and links S6K1 to the mTOR pathway. Although the function of SKAR has not been elucidated, previous studies suggest that it plays an important role in the quality control machinery that checks newly synthesized mRNA for errors and assembles the translation apparatus, thereby regulating the synthesis of new proteins and possible cell growth.
    产品信息
    格式 Affinity Purified
    控制
    • Raji cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-SKAR Antibody detects level of SKAR & has been published & validated for use in Western Blotting, ICC.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected SKAR in HeLa cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human SKAR.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    品种反应性 RatHuman
    Species Reactivity Note Demonstrated to react with Human and Rat. Other homologies: Mouse (93% sequence homology).
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_115687
    Entrez基因汇总 This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit. This protein is a specific target of S6 kinase 1 and regulates cell growth. Two transcript variants that encode different protein isoforms have been identified. [provided by RefSeq, Jul 2008].
    基因符号
    • PDIP46
    • POLDIP3
    纯化方法 Affinity purified
    UniProt编号
    • Q9BY77
    UniProt汇总 FUNCTION: Is involved in regulation of translation. Is preferentially associated with CBC-bound spliced mRNA-protein complexes during the pioneer round of mRNA translation. Contributes to enhanced translational efficiency of spliced over nonspliced mRNAs. Recruits activated ribosomal protein S6 kinase beta-1 I/RPS6KB1 to newly synthesized mRNA.

    SUBUNIT STRUCTURE: Interacts with POLD2. Interacts with NCBP1 and EIF4A3. Associates with the multiprotein exon junction complex (EJC). Interacts with RPS6KB1 (activated). Interacts with ERH.

    SUBCELULAR LOCATION: Nucleus. Nucleus speckle. Cytoplasm. Note: Nucleocytoplasmic shuttling protein.

    PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated at Ser-383 and Ser-385 by RPS6KB1.

    SEQUENCE SIMILARITIES: Contains 1 RRM (RNA recognition motif) domain.

    SEQUENCE CAUTION: The sequence BAB33368.2 differs from that shown. Reason: Erroneous initiation.
    产品使用声明
    质量保证 Evaluated by Western Blot in Raji cell lysate.

    Western Blot Analysis: 0.05 µg/mL of this antibody detected SKAR on 10 µg of Raji cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABS157,Anti-SKAR Antibody

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