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merck millipore,默克密理博,HTS081RTA,Ready-to-Assay™ TP Prostanoid Receptor Frozen Cells
产品名称：Ready-to-Assay™ TP Prostanoid Receptor Frozen Cells
产品型号：HTS081RTA
Human TP / TXA2 / PGH2 GPCR frozen cells for Calcium Flux FLIPR Assays & cAMP Assays.
merck millipore,默克密理博,HTS081RTA,Ready-to-Assay™ TP Prostanoid Receptor Frozen Cells
- 产品介绍
重要规格表
应用说明 品种 宿主细胞 蛋白靶 Calcium Flux Assays; cAMP Assays Human Chem-1 TP / TXA2 / PGH2 描述 产品目录编号 HTS081RTA 商名 - Ready-to-Assay
描述 Ready-to-Assay™ TP Prostanoid Receptor Frozen Cells 背景信息 Millipore’s Ready-to-Assay GPCR frozen cells are designed for simple, rapid calcium assays with no requirement for intensive cell culturing. Millipore has optimized the freezing conditions to provide cells with high viability and functionality post-thaw. The user simply thaws the cells and resuspends them in media, dispenses cell suspension into assay plates and, following over night recovery, assays for calcium response.
TP receptors (Thromboxane A2 receptors) are widely distributed among different organ systems and have been localized on both cell membranes and intracellular structures. TP receptors belong to G protein-coupled receptor family (Hirata et al., 1991). Activation of TP receptors induces platelet aggregation, vascular and respiratory smooth muscle constriction, and enhances mitogenic responses of vascular smooth muscle cells that are stimulated by growth factors (Ali et al., 1993; Hanasaki et al., 1990). The human TP receptor is encoded by a single gene that is alternatively spliced at the carboxyl terminus, resulting in two isoforms, TPα (343 residues) and TPα (407 residues). Both isoforms couple to Gq pathway, but couple oppositely to adenylate cyclase. Millipore’s cloned human TP-expressing cell line is made in the Chem-1 host, which supports high levels of recombinant TP expression on the cell surface and contains high levels of the promiscuous G protein Gα15 to couple the receptor to the calcium signaling pathway. Thus, the cell line is an ideal tool for screening for agonists, antagonists, and modulators at TP.产品信息 部件 - Fifty (50) mL of Media Component.
- Pack contains 2 vials of mycoplasma-free cells, 1 ml per vial.
检测方法 Fluorescent 应用 应用 Human TP / TXA2 / PGH2 GPCR frozen cells for Calcium Flux FLIPR Assays & cAMP Assays. 应用说明 Calcium Flux Assays; cAMP Assays 生物信息 品种 Human Entrez基因编号 - NM_001060
GPCR类别 A 宿主细胞 Chem-1 蛋白靶 TP / TXA2 / PGH2 靶子系列 Prostanoid 细胞系类型 - Ready-to-Assay
产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
- This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck-Millipore to request certain information about you and the establishment where the GMOs are being handled.
包装信息 数量 1 kit
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