merck millipore,默克密理愽
  • merck millipore,默克密理博,ABN454,Anti-Tau (T22), oligomeric Antibody

  • merck millipore,默克密理博,ABN454,Anti-Tau (T22), oligomeric Antibody

    产品名称：Anti-Tau (T22), oligomeric Antibody
    产品型号：ABN454
    This Anti-Tau (T22) antibody, oligomeric is validated for use in western blotting, dot blot, IHC, ICC, neutralizing & IP for the detection of Tau (T22).

    merck millipore,默克密理博,ABN454,Anti-Tau (T22), oligomeric Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABN454,Anti-Tau (T22), oligomeric Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MICC, WB, IHCRbSerumPolyclonal Antibody
    描述
    产品目录编号 ABN454
    描述 Anti-Tau (T22), oligomeric Antibody
    Alternate Names
    • PHF-tau, Oligomeric Tau
    • Microtubule-associated protein tau
    • Neurofibrillary tangle protein
    • Paired helical filament-tau
    背景信息 In Alzheimer's disease (AD) pathology, accumulation of the microtubule-associated protein tau takes place primarily in the neurons. Tau accumulates in both the somatodendritic and axonal domains of neurons. Tau also accumulates in the soma as neurofibrillary tangles (NFTs). Cell death and synaptic lesions occur independently of NFT formation, and research indicates that NFT formation alone is insufficient for neurodegeneration. This suggests that soluble tau aggregates may be the most toxic and pathologically significant tau species. Tau oligomers are neurotoxic when applied extracellularly to cultured neuronal cells tau oligomers (but not fibrils) induce neurodegeneration and synaptic and mitochondrial dysfunction in vivo. Moreover using a new Tau oligomer specific antibody, Tau (T22), researchers were able to use tau oligomers as a reliable biomarker to differentiate patients with AD from age-matched controls. Tau (T22) should further allow researchers to begin to analyze the relation between tau aggregation, amyloid, and disease progression.
    产品信息
    格式 Serum
    演示 Rabbit polyclonal serum containing 0.05% sodium azide.
    应用
    应用 This Anti-Tau (T22) antibody, oligomeric is validated for use in western blotting, dot blot, IHC, ICC, neutralizing & IP for the detection of Tau (T22).
    主要应用
    • Immunocytochemistry
    • Western Blotting
    • Immunohistochemistry
    应用说明 Dot Blot (Specificity) Analysis: A 1:1,000 dilution from a representative lot detected Tau oligomers, and not Tau monomers or Tau fibrils.

    Immunohistochemistry Analysis: A representative lot detected Tau (T22), oligomeric in frontal cortices from Alzheimer's Disease and Lewy Body Disease patients. Recommend dilution range of 250-1000 . (Prof. Rakez Kayed, University of Texas, Galveston.)

    Neutralizing Assay Analysis: A representative lot from a representative lot neutralizes oligomer Tau toxicity (Lasagna-Reeves, C. A., et al. (2012). FASEB J. 26(5):1946-1959.; Lasagna-Reeves, C. A., et al (2012). Sci Rep. 2:700.).

    Immunocytochemistry Analysis: A representative lot from an indepdent laboratory detected Tau (T22), oligomeric in Neurofibrillary tangles (NFTs) (Wu J. W., et al. (2013). J Biol Chem 2012. 288(3):1856-1870.).

    Immunoprecipitation Analysis: A representative lot from an indepdent laboratory immunoprecipitated Tau (T22), oligomeric from Alzheimer's Disease patients (Lasagna-Reeves, C. A., et al. (2012). FASEB J. 26(5):1946-1959.; Lasagna-Reeves, C. A., et al (2012). Sci Rep. 2:700.).
    生物信息
    免疫原品种 Tau oligomers corresponding to human oligomeric Tau (T22).
    宿主 Rabbit
    特异性 This antibody is specific for oligomeric Tau, not with monomer Tau or fibril Tau. This ab neutralizes oligomer Tau toxicity.
    品种反应性 RatHumanMouse
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001116538
    基因符号
    • TAU
    • MAPT
    • MAPTL
    • MTBT1
    纯化方法 Unpurified
    UniProt编号
    • P10636
    产品使用声明
    质量保证 Evaluated by Western Blotting in normal and Alzheimer's Disease brain tissue lysate.

    Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Tau (T22), oligomeric in Alzheimer's Disease brain tissue lysate and not normal brain tissue lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,ABN454,Anti-Tau (T22), oligomeric Antibody

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