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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN332 描述 Anti-BICD2 Antibody Alternate Names - BICD2
- Bicaudal D homolog 2
- Bic-D 2
背景信息 BICD2 is the second human homolog discovered to the Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. Similar to the highly homologous protein BICD1, BICD2 can bind to dynein-dynactin complex, primarily through the dynamitin subunit of dynactin. The C-terminus of BICD2 targets the protein to the Golgi complex while the N-terminal domain of BICD2 co-immunoprecipitates with cytoplasmic dynein, suggesting BICD2 plays a role in the dynein-dynactin interaction on the surface of membranous organelles. Mice engineered to overexpress the BICD2 amino terminal domain in neurons developed amyotrophic lateral sclerosis (ALS)-like features such as Golgi fragmentation, neurofilament swelling in proximal axons, etc., suggesting that impaired dynein/dynactin function may explain some of the pathological features observed in ALS patients. 产品信息 格式 Affinity Purified 控制 - Human lung tissue lysate
演示 Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide. 应用 应用 Anti-BICD2 detects levels of BICD2 proteins & has been published & validated for use in WB & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected BICD2 in human cerebellum tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human BICD2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody will not cross-react with BICD1. 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - BICD2
纯化方法 Antigen Affinity purified UniProt编号 - Q8TD16
产品使用声明 质量保证 Evaluated by Western Blot in human lung tissue lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected BICD2 in 10 µg/mL of human lung tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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