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merck millipore,默克密理博,361559,GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem
产品名称：GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem
产品型号：361559
The GSK-3 Inhibitor XVI, also referenced under CAS 252917-06-9, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation appli More>>
merck millipore,默克密理博,361559,GSK-3 Inhibitor XVI - CAS 252917-06-9 - Calbiochem
- 产品介绍
重要规格表
经验配方 CAS号 C₂₂H₁₈Cl₂N₈ 252917-06-9 描述 概述 A cell-permeable aminopyrimidine compound that acts as potent, ATP-competitive, and highly selective GSK-3 inhibitor (IC50 = 10 and 6.7 nM against GSK-3α and GSK-3β, respectively). Exhibits little or no activity toward 46 other enzymes (IC50 >8.8 µM against 20 kinases and Ki ≥5 µM against 23 non-kinase enzymes) and shows only weak binding to 22 pharmacologically relevant receptors (Kd ~4 µM). This compound is orally available and is shown to effectively improve glucose metabolism in both murine and rat type 2 diabetes models in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 361571). 产品目录编号 361559 品牌系列 Calbiochem®
同义词 6-(2-(4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino)ethyl-amino)-nicotinonitrile, CHIR99021 参考 参考 Mussmann, R., et al. 2007. J. Biol. Chem. 282, 12030.
Ring, D.B., et al. 2003. Diabetes 52, 588.
Bennett, C.N., et al. 2002. J. Biol. Chem. 277, 30998.
Cline, G.W., et al. 2002. Diabetes 51, 2903.产品信息 CAS号 252917-06-9 形式 Light beige solid Hill配方 C₂₂H₁₈Cl₂N₈ 化学配方 C₂₂H₁₈Cl₂N₈ Molar Mass 465.3 结构配方图像 生物信息 纯度 ≥97% by HPLC 理化信息 溶解度 DMSO 安全信息 R相 R: 22
Harmful if swallowed.S相 S: 22-24/25-36-45
Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).储存和货运信息 货运代码 Ambient Temperature Only
毒性 Harmful
储存 +2°C to +8°C
避光 Protect from light
无需冷冻 No
特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. 包装信息 惰性气体下包装 Packaged under inert gas
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