- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H, R IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN328 描述 Anti-Rcan2 Antibody Alternate Names - Calcipressin-2
- Rcan2
- Regulator of calcineurin 2
- ZAKI4
- DSCR1L1
背景信息 Calcipressin-2 (Rcan2), also known as ZAKI4 and DSCR1L1, is expressed as two isoforms differing at their N-terminus. The longer of the two (isoform 1) is expressed exclusively in the brain, while isoform 2 is ubiquitously expressed, with highest expression in brain, heart, and muscle. Both isoforms bind to the catalytic subunit of calcineurin, a Ca++-dependent protein phosphatase involved in several neuronal functions, though their C-terminal region and inhibit calcineurin’s activity. Unlike isoform 1 of Anti-Rcan2, the expression of the second isoform is not induced by the thyroid hormone T3. Anti-Rcan2 is a member of a family of three endogenous calcineurin regulators that are located near the minimal supernumerary fragment of chromosome 21 in individuals with Down syndrome, suggesting that they play a role in this syndrome. Multiple isoforms of Rcan2 are known to exist. 产品信息 格式 Affinity Purified 控制 - PC12 cell lysate
演示 Purified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide. 应用 应用 This Rcan2 antibody is validated for use in WB & IHC for the detection of the Rcan2 protein. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Western Blot Analysis: 2 µg/mL from a representative lot detected Rcan2 in 15 µg/mL of NIH/3T3 cell lysate.
Immunohistochemistry Analysis: 1:500-2,000 dilution from a representative lot detected Rcan2 in rat hippocampus and human midbrain tissues.生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to mouse Rcan2. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes isoforms Rcan2-S and Rcan2-L. (Porta, S., et al. (2007). Eur J Neurosci. 26(5):1213-1226.) 品种反应性 MouseHumanRat Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. 抗体类型 Polyclonal Antibody 基因符号 - RCAN2
纯化方法 Antigen Affinity purified UniProt编号 - Q9JHG2
产品使用声明 质量保证 Evaluated by Western Blot in PC12 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected Rcan2 in 10 µg/mL of PC12 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,ABS10,Anti-SHIP Antibody
下一件merck millipore产品：merck millipore,默克密理博,189485,Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem
相关产品
merck millipore,默克密理博,AB2967,Anti-Stathmin Antibody
merck millipore,默克密理博,SF-1445,GAP43; Mouse, Cyanine 3 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,PP64-K,Rabbit IgG Purified (1mg)
merck millipore,默克密理博,ABC61,Anti-NIPP-1 Antibody
merck millipore,默克密理博,ABS10,Anti-SHIP Antibody
merck millipore,默克密理博,05-1359,Anti-RXR alpha Antibody, clone 4E9
merck millipore,默克密理博,ST1699,Anti-NDE1 Mouse mAb (2G11-1C11)
merck millipore,默克密理博,04-239,Anti-p16/INK4a Antibody, clone EP435Y, rabbit monoclonal
merck millipore,默克密理博,SF-1548,MYD88; Human, Cyanine 5 RNA Detection Probe,SmartFlare