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merck millipore,默克密理博,05-1359,Anti-RXR alpha Antibody, clone 4E9
产品名称：Anti-RXR alpha Antibody, clone 4E9
产品型号：05-1359
Anti-RXR alpha Antibody, clone 4E9 is a Mouse Monoclonal Antibody for detection of RXR α also known as Retinoid X receptor alpha & has been validated in WB, ICC.
merck millipore,默克密理博,05-1359,Anti-RXR alpha Antibody, clone 4E9
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H ICC, WB M Purified Monoclonal Antibody 描述 产品目录编号 05-1359 描述 Anti-RXR alpha Antibody, clone 4E9 Alternate Names - retinoid X receptor, alpha
- Nuclear receptor subfamily 2 group B member 1
- Retinoid X receptor alpha
背景信息 Retinoid X receptor α (RXRA or RXR alpha) is a nuclear receptor that mediates the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. RXRs as a whole exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulate their transcription. 产品信息 格式 Purified 控制 - MCF-7 cell lysate
演示 Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide. 应用 应用 Anti-RXR alpha Antibody, clone 4E9 is a Mouse Monoclonal Antibody for detection of RXR α also known as Retinoid X receptor alpha & has been validated in WB, ICC. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry: Representative lot data.
A 1:500 dilution of a previous lot detected Retinoid X Receptor α in A431 cells.
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to Retinoid X Receptor α. 克隆 4E9 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Mouse 特异性 This antibody detects Retinoid X Receptor α. 同种型 IgG2aκ 品种反应性 Human Species Reactivity Note Human 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_002948.1
Entrez基因汇总 Retinoid X receptors (RXRs) and retinoic acid receptors (RARs), are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors exert their action by binding, as homodimers or heterodimers, to specific sequences in the promoters of target genes and regulating their transcription. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. [provided by RefSeq].
基因符号 - OTTHUMP00000022510
- FLJ00280
- FLJ00318
- FLJ16020
- FLJ16733
- MGC102720
- NR2B1
纯化方法 Protein G purfied UniProt编号 - P19793
UniProt汇总 FUNCTION: Nuclear hormone receptor. Involved in the retinoic acid response pathway. Binds 9-cis retinoic acid (9C-RA). ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer By similarity.
SUBUNIT STRUCTURE: Homodimer or forms a heterodimer with peroxisome proliferator activated receptor gamma called adipocyte-specific transcription factor ARF6. Interacts with NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with FAM120B By similarity. Interacts with SFPQ. Interacts with HCV core protein. Interacts with PELP1. Interacts with SENP6. Interacts with DNTTIP2. Interacts with RNF8.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICITY: Highly expressed in liver, also found in lung, kidney and heart.
DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal steroid-binding domain.
PTM: Sumoylated on Lys-108; which negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR2 subfamily.
Contains 1 nuclear receptor DNA-binding domain.
产品使用声明 质量保证 Evaluated by western blot on MCF-7 cell lysate.
Western Blot Analysis: 0.5-2 µg/mL of this antibody detected Retinoid X Receptor α in MCF-7 cell lysate.
使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8ºC from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,189485,Autocamtide-2 Related Inhibitory Peptide II, Cell-permeable - Calbiochem
下一件merck millipore产品：merck millipore,默克密理博,ST1699,Anti-NDE1 Mouse mAb (2G11-1C11)
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