- 当前位置：首页 > >Merck Millipore > 生命科学研究
- 生命科学研究
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 Ca, H, B, Chp, Rhesus Macaque, Po WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABN30 描述 Anti-Aromatase Antibody Alternate Names - Estrogen synthase
- Cytochrome P450 19A1
- Aromatase
- CYPXIX
- Cytochrome P-450AROM
背景信息 Human Aromatase is a membrane-bound enzyme that is localized on the endoplasmic reticulum. While it is found in gonads and adrenal glands where it converts androgens into estrogens in a classical endocrine manner, it is also expressed in various tissues where it regulates local estrogen levels or estrogen/androgen ratios in an intracrine manner. Human Aromatase is known to have two major forms, characterized by one amino acid difference at amino acid position 264 [arginine (264R) and cysteine (264C)]. Abnormal Aromatase hyperactivity is a known cause for Aromatase excess syndrome (AES), which is characterized by excess levels of estrogen, heterosexual precocity in adolescent males and isosexual precocity in adolescent females. On the other hand, Aromatase deficiency (AROD) in Aromatase-deficient (ArKO) mice leads to increased adiposity, an inability to synthesize estrogen, birth defects, and genital-related developmental disorders. It is also reported to play a role in a complex immune-neuro-endocrine network management system in murine cysticercosis. 产品信息 格式 Affinity Purified 控制 - Human placenta tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Aromatase Antibody is an antibody against Aromatase for use in WB. 主要应用 - Western Blotting
应用说明 Western Blot Analysis: 1 µg/mL from a representative lot detected Aromatase in 10 µg of human testis. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Aromatase. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 CanineHumanBovineChimpanzeeRhesus MacaquePig Species Reactivity Note Demonstrated to react with Human. Predicted to react with Bovine, Chimpanzee, Rhesus Macaque, Porcine, and Canine based on 100% sequence homology. Other homolgoies: Rat and Mouse (94% sequence homology). 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_000094
Entrez基因汇总 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. 基因符号 - CYP19
- CYP19A1
- ARO1
- CYAR
纯化方法 Affinity purified UniProt编号 - P11511
UniProt汇总 FUNCTION: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.
CATALYTIC ACTIVITY: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
COFACTOR: Heme group.
SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Brain, placenta and gonads.产品使用声明 质量保证 Evaluated by Western Blot in human placenta tissue lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected Aromatase in 10 µg of human placenta tissue lysate. Tween was not used in the Western Blot.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
上一件merck millipore产品：merck millipore,默克密理博,SF-1217,PARK7; Human, Cyanine 5 RNA Detection Probe,SmartFlare
下一件merck millipore产品：merck millipore,默克密理博,MZFBN0W50,MultiScreenHTS 384 FB，1.0/0.65 µm，不透明，非无菌
相关产品
merck millipore,默克密理博,HTS131RTA,Ready-to-Assay™ IP1 Prostanoid Receptor Frozen Cells
merck millipore,默克密理博,GF305,IFN- γ Protein, Human Recombinant Animal Free
merck millipore,默克密理博,ABF209,Anti-SLAMF2 (CD48 Antibody)
merck millipore,默克密理博,14-906,PI3K-C2α Protein, 10 µg
merck millipore,默克密理博,SF-1217,PARK7; Human, Cyanine 5 RNA Detection Probe,SmartFlare
merck millipore,默克密理博,MZFBN0W50,MultiScreenHTS 384 FB，1.0/0.65 µm，不透明，非无菌
merck millipore,默克密理博,MAB570,Anti-Heparin Antibody, clone A7.10
merck millipore,默克密理博,124036,Akt Inhibitor XVIII, SC66 - Calbiochem
merck millipore,默克密理博,16-663X,Magna ChIP™ Protein A+G Magnetic Beads
merck millipore,默克密理博,CBL309,Mouse Anti-Human IgG1 Antibody, clone 8c/6-39, Fc