merck millipore,默克密理愽
  • merck millipore,默克密理博,124036,Akt Inhibitor XVIII, SC66 - Calbiochem

  • merck millipore,默克密理博,124036,Akt Inhibitor XVIII, SC66 - Calbiochem

    产品名称：Akt Inhibitor XVIII, SC66 - Calbiochem
    产品型号：124036
    The Akt Inhibitor XVIII, SC66 controls the biological activity of Akt. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

    merck millipore,默克密理博,124036,Akt Inhibitor XVIII, SC66 - Calbiochem

  • 产品介绍
  • merck millipore,默克密理博,124036,Akt Inhibitor XVIII, SC66 - Calbiochem

    重要规格表

    经验配方
    C₁₈H₁₆N₂O
    描述
    概述 A cell-permeable pyridine compound that selectively targets Akt, but not PLCδ, PH domain, preventing Akt membrane localization/activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 (Cat. Nos. 124017 & 124018) competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4 µM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30 mg/kg), Synergizes with LY294002 (Cat. Nos. 440202 & 440204) in cell death induction in HeLa and HS-Sultan cultures in vitro.
    产品目录编号 124036
    品牌系列 Calbiochem®
    同义词 (2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone
    参考
    参考 Jo, H., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 6486.
    产品信息
    形式 Pale yellow solid
    Hill配方 C₁₈H₁₆N₂O
    化学配方 C₁₈H₁₆N₂O
    Molar Mass 276.3
    结构配方图像
    生物信息
    纯度 ≥98% by HPLC
    理化信息
    溶解度 DMSO
    储存和货运信息
    货运代码 Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
    毒性 Regulatory Review
    储存 +2°C to +8°C
    避光 Protect from light
    无需冷冻 No
    特殊指南 Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
    包装信息
    惰性气体下包装 Packaged under inert gas

    merck millipore,默克密理博,124036,Akt Inhibitor XVIII, SC66 - Calbiochem

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