merck millipore,默克密理博,ABN299,Anti-triphospho-PER2 Antibody (Ser662/Ser665/Ser668)

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merck millipore,默克密理博,ABN299,Anti-triphospho-PER2 Antibody (Ser662/Ser665/Ser668)
产品名称：Anti-triphospho-PER2 Antibody (Ser662/Ser665/Ser668)
产品型号：ABN299
Detect PER 2 using this rabbit polyclonal antibody, Anti-triphospho-PER2 Antibody (Ser662/Ser665/Ser668) validated for use in western blotting.

merck millipore,默克密理博,ABN299,Anti-triphospho-PER2 Antibody (Ser662/Ser665/Ser668)

产品介绍

merck millipore,默克密理博,ABN299,Anti-triphospho-PER2 Antibody (Ser662/Ser665/Ser668)

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H	WB	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	ABN299
描述	Anti-triphospho-PER2 Antibody (Ser662/Ser665/Ser668)
Alternate Names	Circadian clock protein PERIOD 2 Period circadian protein homolog 2 hPER2
背景信息	Period circadian protein homolog 2 (PER2), or Circadian clock protein PERIOD2, is a component of the circadian clock mechanism which is essential for generating circadian rhythms. It is a negative element in the circadian transcriptional loop by Influencing clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. PER2 negatively regulates CLOCK NPAS2-BMAL1 BMAL2-induced transactivation. This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior.

产品信息
格式	Purified
控制	Untreated and lambda phosphatase treated HEK293 cell lysates transfected with Myc-tagged triphospho PER2 (Ser662/Ser665/Ser668).
演示	Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide and 50% glycerol.

应用
应用	Detect PER 2 using this rabbit polyclonal antibody, Anti-triphospho-PER2 Antibody (Ser662/Ser665/Ser668) validated for use in western blotting.
主要应用	Western Blotting
应用说明	Western Blotting Analysis: A representative lot detected triphospho PER2 (Ser662/Ser665/Ser668) in Flag-tagged triphospho PER2 (Ser662/Ser665/Ser668) transfected HEK293T cell lysates (Hutchinson, J. A., et al. (2011). J Biol Chem. 286(10):8688-8696.).

生物信息
免疫原品种	Linear peptide corresponding to human triphospho PER2 (Ser662/Ser665/Ser668).
宿主	Rabbit
特异性	This antibody demonstrates cross reactivity against phospho RPS6 (Ser247) (Hutchinson, J. A., et al. (2011). J Biol Chem. 286(10):8688-8696.). This antibody requires that all three amino acid sites (Ser662/Ser665/Ser668) be phosphorylated for the detection of phospho-PER2 (Ser662/Ser665/Ser6668) (Shanware, N. P., et al. (2011). J Biol Chem. 286(14):12766-12774.).
品种反应性	Human
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_073728
基因符号	PER2
纯化方法	Affinity purified
UniProt编号	O15055

产品使用声明
质量保证	Evaluated by Western Blotting in untreated and lambda phosphatase treated HEK293 cell lysates transfected with Myc-tagged triphospho PER2 (Ser662/Ser665/Ser668). Western Blotting Analysis: A 1:250 dilution from a representative lot detected Myc-tagged triphospho PER2 (Ser662/Ser665/Ser668) in 10 µg of untreated HEK293 cell lysates, and demonstrated a loss of signal in 10 µg of lambda phosphatase treated HEK293 cell lysates.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

产品使用声明

质量保证

Evaluated by Western Blotting in untreated and lambda phosphatase treated HEK293 cell lysates transfected with Myc-tagged triphospho PER2 (Ser662/Ser665/Ser668).

Western Blotting Analysis: A 1:250 dilution from a representative lot detected Myc-tagged triphospho PER2 (Ser662/Ser665/Ser668) in 10 µg of untreated HEK293 cell lysates, and demonstrated a loss of signal in 10 µg of lambda phosphatase treated HEK293 cell lysates.

使用声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.