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  • merck millipore,默克密理博,ABE64,Anti-ERR-alpha P2 Antibody

  • merck millipore,默克密理博,ABE64,Anti-ERR-alpha P2 Antibody

    产品名称：Anti-ERR-alpha P2 Antibody
    产品型号：ABE64
    Use Anti-ERR-alpha P2 Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect ERR-alpha P2 also known as Estrogen receptor-like 1, Estrogen-related receptor alpha.

    merck millipore,默克密理博,ABE64,Anti-ERR-alpha P2 Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE64,Anti-ERR-alpha P2 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HICC, WBRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE64
    Replaces 04-1134
    描述 Anti-ERR-alpha P2 Antibody
    Alternate Names
    • estrogen-related receptor alpha
    • Estrogen receptor-like 1
    • Estrogen-related receptor, alpha
    • Nuclear receptor subfamily 3 group B member 1
    背景信息 ERR alpha is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site specific transcription regulator and has also been shown to interact with estrogen and the transcription factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium chain acyl coenzyme A dehydrogenase (MCAD),and thyroid hormone receptor genes. ERR alpha is expressed in many adult and embryonic tissues (particularly at the onset of ossification) as well as in several osteoblast cell lines. ERR alpha expression has been documented in brain, spinal cord, pituitary gland and heart. More recently, ERR alpha has been observed in various human breast cancer cell lines, breast adipose tissue and breast tumors. Studies demonstrating the use of ERR alpha antagonists in treating breast cancer have excited great interest in this receptor in the search for curing the disease (Chisamore, 2009).
    产品信息
    格式 Purified
    控制
    • HeLa cell lysate
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Use Anti-ERR-alpha P2 Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect ERR-alpha P2 also known as Estrogen receptor-like 1, Estrogen-related receptor alpha.
    主要应用
    • Immunocytochemistry
    • Western Blotting
    应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected ERR-alpha in A431 and HeLa cells.
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human ERR-alpha.
    表位 Unknown
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes ERR-alpha.
    同种型 IgG
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with human and mouse.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_004442
    Entrez基因汇总 The protein encoded by this gene is a nuclear receptor that is closely related to the estrogen receptor. This protein acts as a site-specific transcription regulator and has been also shown to interact with estrogen and the transcripton factor TFIIB by direct protein-protein contact. The binding and regulatory activities of this protein have been demonstrated in the regulation of a variety of genes including lactoferrin, osteopontin, medium-chain acyl coenzyme A dehydrogenase (MCAD) and thyroid hormone receptor genes. A processed pseudogene of ESRRA is located on chromosome 13q12.1. [provided by RefSeq].
    基因符号
    • NR3B1
    • ERR-alpha
    • ERR1
    • ERRa
    • ERRalpha
    • ESRL1
    纯化方法 Protein A purfied
    UniProt编号
    • P11474
    UniProt汇总 FUNCTION: Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism.

    SUBUNIT STRUCTURE: Binds DNA as a monomer or a homodimer. Interacts (via the AF2 domain) with coactivator PPARGC1A (via the L3 motif); the interaction greatly enhances transriptional activity of genes involved in energy metabolism. Interacts with PIAS4; the interaction enhances sumoylation.

    SUBCELLULAR LOCATION: Nucleus

    INDUCTION: Induced by PGC1alpha in a number of specific cell types including heart, kidney and muscle.

    PTM: Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.

    Sumoylated by SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activiy, but has no effect on subcellular location nor on DNA binding.

    SEQUENCE SIMILARITIES: Belongs to the nuclear hormone receptor family. NR3 subfamily.

    Contains 1 nuclear receptor DNA-binding domain.

    SEQUENCE CAUTION: The sequence CAA35778.1 differs from that shown. Reason: Frameshift at positions 345 and 354.
    产品使用声明
    质量保证 Evaluated by Western Blot in HeLa cell lysate.

    Western Blot Analysis: 2 µg/mL of this antibody detected ERR-alpha on 10 µg of HeLa cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 100 µg

    merck millipore,默克密理博,ABE64,Anti-ERR-alpha P2 Antibody

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