merck millipore,默克密理博,ABE491,Anti-Histone-lysine N-methyltransferase NSD3 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H	IHC, WB	Rb	Affinity Purified	Polyclonal Antibody

描述
产品目录编号	ABE491
描述	Anti-Histone-lysine N-methyltransferase NSD3 Antibody
Alternate Names	WHSC1-like protein 1 Histone-lysine N-methyltransferase NSD3 Nuclear SET domain-containing protein 3 Protein whistle WHSC1-like 1 isoform 9 with methyltransferase activity to lysine Wolf-Hirschhorn syndrome candidate 1-like protein 1
背景信息	Histone-lysine N-methyltransferase NSD3, also known as Nuclear SET domain-containing protein 3, Protein whistle, WHSC1-like 1 isoform 9 with methyltransferase activity to lysine or Wolf-Hirschhorn syndrome candidate 1-like protein 1, (WHSC1-like protein 1), and encoded by the gene WHSC1L1/NSD3, is a histone methylase that preferentially methylates Lys-4 and Lys-27 of histone H3. Lys-4 methylation is generally a specific tag for transcriptional activation while Lys-27 methylation is a mark for transcriptional repression. NSD3 is highly expressed in many tissues including the brain, heart and skeletal muscle. Overexpression of NSD3 is associated with certain forms of lung cancer as well as certain other cancers. NSD3 also facilitates the expression of many other genes important in cancer progression such as Brd4. Brd4 through its extraterminal domain interacts with NSD3 which regulates transcription by modifying the chromatin microenvironment at Brd4 target genes.

产品信息
格式	Affinity Purified
演示	Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

应用
应用	Detect Histone-lysine N-methyltransferase NSD3 using this rabbit polyclonal antibody, Anti-Histone-lysine N-methyltransferase NSD3 Antibody validated for use in western blotting & IHC.
主要应用	Immunohistochemistry Western Blotting
应用说明	Immunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Histone-lys N-methyltransferase NSD3 in human and mouse cerebellum tissues.

生物信息
免疫原品种	KLH-conjugated linear peptide corresponding to a region near the N-terminus of human Histone-lys N-methyltransferase NSD3.
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
特异性	This antibody is expected to cross react with isofomrs 1, 2, and 4 based upon immunogen design.
品种反应性	MouseHuman
Species Reactivity Note	Demonstrated to react with Human and Mouse.
抗体类型	Polyclonal Antibody
Entrez基因编号	NP_075447
基因符号	DC28 WHSC1L1 NSD3
纯化方法	Affinity purified
UniProt编号	Q9BZ95

产品使用声明
质量保证	Evaluated by Western Blotting in BALB/3T3 nuclear extract. Western Blotting Analysis: 2 µg/mL of this antibody detected Histone-lys N-methyltransferase NSD3 in 10 µg of BALB/3T3 nuclear extract.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at 2-8°C from date of receipt.

包装信息
数量	200 µg

merck millipore,默克密理博,ABE491,Anti-Histone-lysine N-methyltransferase NSD3 Antibody

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