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merck millipore,默克密理博,ABE48,Anti-NELF-E Antibody
产品名称：Anti-NELF-E Antibody
产品型号：ABE48
Anti-NELF-E Antibody is a Rabbit Polyclonal Antibody for detection of NELF-E also known as Negative elongation factor E, NELF-E, RNA-binding protein RD & has been validated in ICC & WB.
merck millipore,默克密理博,ABE48,Anti-NELF-E Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, R, Ca, B, H WB, ICC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE48 描述 Anti-NELF-E Antibody Alternate Names - RNA-binding protein RD
- Negative elongation factor E
- NELF-E
背景信息 NELF-E (Negative elongation factor E) is a main component of NELF human transcription factor complex which associates with DRB sensitivity-inducing factor to stifle transcriptional elongation by RNA polymerase II. NELF-E is an RNA-binding protein that includes arginine-aspartic acid dipeptide repeats. NELF-E RNA-binding activity is essential for NELF to function. 产品信息 格式 Affinity Purified 控制 - L6 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-NELF-E Antibody is a Rabbit Polyclonal Antibody for detection of NELF-E also known as Negative elongation factor E, NELF-E, RNA-binding protein RD & has been validated in ICC & WB. 主要应用 - Western Blotting
- Immunocytochemistry
应用说明 Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected NELF-E in NIH/3T3 and HeLa cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human NELF-E. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 MouseRatCanineBovineHuman Species Reactivity Note Demonstrated to react with Human, Mouse, and Rat. Predicted to react with Canine and Bovine based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002895
Entrez基因汇总 The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq]. 基因符号 - RD
- RDBP
- NELFE
纯化方法 Affinity purified UniProt编号 - P18615
UniProt汇总 FUNCTION: Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. SUBUNIT STRUCTURE: The NELF complex is composed of 4 subunits: WHSC2/NELF-A, COBRA1/NELF-B, TH1L (isoform NELF-C or isoform NELF-D) and RDBP/NELF-E.
SUBCELLULAR LOCATION: Nucleus.
TISSUE SPECIFICTY: Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.
DOMAIN: The RRM domain interacts with RNA, and is essential for NELF complex function. It is however not required for the NELF complex formation. Ref.9
PTM: Sumoylated.
SEQUENCE SIMILARITIES: Belongs to the RRM NELF-E family.
Contains 1 RRM (RNA recognition motif) domain.产品使用声明 质量保证 Evaluated by Western Blot in L6 cell lysate.
Western Blot Analysis: 0.5 µg/mL of this antibody detected NELF-E on 10 µg of L6 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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