merck millipore,默克密理博,431050,InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4

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merck millipore,默克密理博,431050,InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem
产品名称：InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem
产品型号：431050
An antifungal antibiotic that acts as an inhibitor of nuclear export because of its ability to interact with and impair the function of the nuclear export factor CRM1.

merck millipore,默克密理博,431050,InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem

产品介绍

merck millipore,默克密理博,431050,InSolution™ Leptomycin B, Streptomyces sp. - CAS 87081-35-4 - Calbiochem

重要规格表

经验配方	CAS号
C₃₃H₄₈O₆	87081-35-4

描述
概述	An antifungal antibiotic that acts as an inhibitor of nuclear export because of its ability to interact with and impair the function of the nuclear export factor CRM1. It is about twice as potent as Leptomycin A (Cat. No. 431051) in inhibiting nucleocytoplasmic translocation of Rev, blocks the Rev-dependent export of mRNA into cytoplasm, and suppresses HIV-1 replication in primary human monocytes (IC₅₀ = 600 pM). In addition, LMB effectively induces the accumulation of p53 in the nucleus of normal fibroblasts as well as protects p53 from Mdm2-mediated ubiquitination and degradation.
概述	Caution! Product contains volatile liquid. Keep product cold at all times.
产品目录编号	431050
品牌系列	Calbiochem®
同义词	LMB, Chromosome Region Maintenance 1 Protein Inhibitor I, CRM1 Inhibitor I, Exportin 1 Inhibitor I, XPO1 Inhibitor I

参考
参考	Kau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78. Menendez, S., et al. 2003. Br. J. Cancer 88, 636. Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66. Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112. Lain, S., et al. 1999. Exp. Cell Res. 248, 457. Wolff, B., et al. 1997. Chem. Biol. 4, 139. Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150. Komiyama, K., et al. 1985. J. Antibiot. 38, 427.

参考

Kau, T.R., and Silver, P.A. 2003. Drug Discov. Today 8, 78.
Menendez, S., et al. 2003. Br. J. Cancer 88, 636.
Xirodimas, D.P., et al. 2001. Exp. Cell Res. 270, 66.
Kudo, N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 9112.
Lain, S., et al. 1999. Exp. Cell Res. 248, 457.
Wolff, B., et al. 1997. Chem. Biol. 4, 139.
Yoshida, M., et al. 1990. Exp. Cell Res. 187, 150.
Komiyama, K., et al. 1985. J. Antibiot. 38, 427.

产品信息
CAS号	87081-35-4
具有ATP竞争性	N
形式	Liquid
配方	Supplied at 20 µg/ml (5 µg in 250 µl) in absolute ethanol
Hill配方	C₃₃H₄₈O₆
化学配方	C₃₃H₄₈O₆
Molar Mass	540.7
可逆	N
结构配方图像

生物信息
主靶	HIV-1 replication in primary human monocytes
主靶IC₅₀	600 pM in suppressing HIV-1 replication in primary human monocytes
纯度	≥95% by HPLC

理化信息
细胞可渗透	N

储存和货运信息
货运代码	Dry Ice Only
毒性	Flammable
有害材料注意事项：	Due to the nature of the Hazardous Materials in this shipment, additional shipping chargesmay be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
储存	≤ -70°C
避光	Protect from light
无需冷冻	No
特殊指南	Following initial use, aliquot and freeze (-70°C).