merck millipore,默克密理愽
  • merck millipore,默克密理博,ABE386,Anti-Flightless-1 homolog Antibody

  • merck millipore,默克密理博,ABE386,Anti-Flightless-1 homolog Antibody

    产品名称：Anti-Flightless-1 homolog Antibody
    产品型号：ABE386
    Detect Fli1 using this rabbit polyclonal antibody, Anti-Flightless-1 homolog Antibody validated for use in western blotting & IP.

    merck millipore,默克密理博,ABE386,Anti-Flightless-1 homolog Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE386,Anti-Flightless-1 homolog Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 ABE386
    Replaces MABF195; MABE530
    描述 Anti-Flightless-1 homolog Antibody
    Alternate Names
    • Anti-Flightless-1 homolog Antibody
    • Protein flightless-1 homolog
    • Fli1
    背景信息 Mammalian homolog of drosophila flightless-1 is encoded by the FLII gene in human (also known as FLI, Fli1, or FLIL). The human flightless-1 homolog (Flii) contains sixteen 23-amino acid leucine-rich repeats (LRR) in its N-terminal half and a gelsolin-like domain (GLD) in its C-terminal half, composed of six segmental repeats typical of many gelsolin family members. Flii is reported to interact with actin and "FLI LRR associated protein" (FLAP) via its GLD and LRR domain, respectively (PMID 9525888). Flii is also shown to interact with the glucose-responsive transcription factor carbohydrate responsive element binding protein (ChREBP) via both the LRR and GLD domains and functions as a negative regulator of ChREBP in cancer cells (PMID 24055811). Increased Flii level is observed in the blistered skin of patients with epidermolysis bullosa acquisita (EBA), and Flii overexpression in transgenic mice results in delayed epidermal barrier formation in embryos and decreased expression of tight junction (TJ) proteins, as well as impaired barrier function among adult transgenic mice (PMID 24375017).
    产品信息
    格式 Serum
    演示 Rabbit polyclonal in buffer containing serum with 0.05% sodium azide.
    应用
    应用 Detect Fli1 using this rabbit polyclonal antibody, Anti-Flightless-1 homolog Antibody validated for use in western blotting & IP.
    主要应用
    • Western Blotting
    应用说明 Immunoprecipitation Analysis: A representative lot of this antibody detected Flightless-1 homolog in IP (Prof. D. Pallas, Emory University).
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to human Flightless-1 homolog.
    宿主 Rabbit
    品种反应性 RatHumanMouse
    Species Reactivity Note Human, Mouse, Rat.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_001243193
    基因符号
    • FLIL
    • FLII
    纯化方法 Unpurified
    UniProt编号
    • Q13045
    产品使用声明
    质量保证 Evaluated by Western Blotting in A431 cell lysate.

    Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Flightless-1 homolog in 10 µg of A431 cell lysate.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at -20°C from date of receipt.
    Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,ABE386,Anti-Flightless-1 homolog Antibody

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