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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE206 描述 Anti-MLL2 (C-Term) Antibody Alternate Names - Myeloid/lymphoid or mixed-lineage leukemia protein 2
- Histone-lysine N-methyltransferase 2D
- Lysine N-methyltransferase 2D
- ALL1-related protein
背景信息 MLL2, also known as Histone-lysine N-methyltransferase 2D, or Lysine N-methyltransferase 2D or ALL1-related protein, or Myeloid/lymphoid or mixed-lineage leukemia protein 2, and encoded by the gene KMT2D/ALR/MLL2/MLL4, is a histone methyltransferase that methylates Lys-4 of histone H3 to form H3K4me. H3K4me represents a specific tag for epigenetic transcriptional activation and for instance in estrogen receptor function where MLL2 acts as coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. MLL2 is also a component of the ASCOM/Mll2/3 complex which plays an important role during development particularly in lymphomagenesis. MLL2 is localized to the nucleus. MLL2 is expressed in most embryonic and adult tissues. Defects in MLL2 are associated with Kabuki syndrome, a congenital mental retardation syndrome with additional features, including postnatal dwarfism, facial and bone deformities. Defects are also associated with medulloblastoma a highly malignant primary brain tumor. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Detect MLL2 (C-Term) using this Anti-MLL2 antibody (C-Term) validated for use in western blotting & IHC. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected MLL2 (C-term) in human breast cancer tissue. 生物信息 免疫原品种 GST-tagged recombinant protein corresponding to the C-terminus of human MLL2 (C-term). 表位 C-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003473
基因符号 - MLL4
- KMT2D
- ALR
- MLL2
纯化方法 Affinity purified UniProt编号 - O14686
产品使用声明 质量保证 Evaluated by Western Blotting in human testis tissue lysate.
Western Blotting Analysis: 1.0 µg/mL of this antibody detected MLL2 (C-term) in 10 µg of human testis tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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