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merck millipore,默克密理博,ABE195,Anti-JMJD1A Antibody
产品名称：Anti-JMJD1A Antibody
产品型号：ABE195
Anti-JMJD1A Antibody is a Rabbit Polyclonal Antibody for detection of JMJD1A also known as lysine (K)-specific demethylase 3A, testis-specific protein AJMJD1A, JMJD1 & has been validated in WB.
merck millipore,默克密理博,ABE195,Anti-JMJD1A Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Serum Polyclonal Antibody 描述 产品目录编号 ABE195 描述 Anti-JMJD1A Antibody Alternate Names - JMJD1
- JMJD
- lysine (K)-specific demethylase 3A
- testis-specific protein A
- jumonji domain containing 1A
- jumonji C domain-containing histone demethylase 2A
- jumonji domain containing 1
- Jumonji domain-containing protein 1A
- JmjC domain-containing histone demethylation protein 2A
- lysine-specific demethylase 3A <br />JMJD1A
背景信息 JMJD1A (jumonji domain-containing 1a), also known as JHDM2A is member of the jumonji (jmj) domain containing gene family of proteins. This protein functions as a histone demethylase that demethylates mono and dimethyl lysine 9 of histone H3. Consequently, this protein plays a role in the regulation of chromatin structure and influences transcriptional activation and suppression. Loss of function of JMJD1A leads to embryonic stem cell differentiation. JMJD1A has also been implicated in smooth muscle cell-specific transcription, hypoxic gene expression and tumor growth. 产品信息 格式 Serum 控制 - HeLa nuclear extract
演示 Rabbit polyclonal serum containing 0.05% sodium azide. 应用 应用 Anti-JMJD1A Antibody is a Rabbit Polyclonal Antibody for detection of JMJD1A also known as lysine (K)-specific demethylase 3A, testis-specific protein A
JMJD1A, JMJD1 & has been validated in WB.主要应用 - Western Blotting
生物信息 免疫原品种 GST-tagged recombinant protein corresponding to human JMJD1A. 宿主 Rabbit 品种反应性 Human Species Reactivity Note Demonstrated to react with human. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_060903.2
Entrez基因汇总 This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. Alternative splicing results in multiple transcript variants. [provided by RefSeq]. 基因符号 - KDM3A
- JHDM2A
- TSGA
- JHMD2A
- JMJD1A
- JMJD1
纯化方法 Unpurified UniProt编号 - Q9Y4C1
UniProt汇总 FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Preferentially demethylates mono- and dimethylated H3 'Lys-9' residue, with a preference for dimethylated residue, while it has weak or no activity on trimethylated H3 'Lys-9'. Demethylation of Lys residue generates formaldehyde and succinate. Involved in hormone-dependent transcriptional activation, by participating in recruitment to androgen-receptor target genes, resulting in H3 'Lys-9' demethylation and transcriptional activation. Involved in spermatogenesis by regulating expression of target genes such as PRM1 and TMP1 which are required for packaging and condensation of sperm chromatin. Involved in obesity resistance through regulation of metabolic genes such as PPARA and UCP1.
COFACTOR: Binds 1 Fe2+ ion per subunit.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note: Nuclear in round spermatids. When spermatids start to elongate, localizes to the cytoplasm where it forms distinct foci which disappear in mature spermatozoa (By similarity).
DOMAIN: The JmjC domain and the C6-type zinc-finger are required for the demethylation activity.
Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors (By similarity).
SEQUENCE SIMILARITIES: Belongs to the JHDM2 histone demethylase family.
Contains 1 JmjC domain.
SEQUENCE CAUTION: The sequence BAA34462.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.产品使用声明 质量保证 Evaluated by Western Blot in HeLa nuclear extract.
Western Blot Analysis: 1:1,000 dilution of this antibody detected JMJD1A on 10 µg of HeLa nuclear extract.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.包装信息 数量 100 µL
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下一件merck millipore产品：merck millipore,默克密理博,71751,LB Broth, Lennox - Novagen
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