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  • merck millipore,默克密理博,ABE186,Anti-acetyl-Histone H4 (Lys77) Antibody

  • merck millipore,默克密理博,ABE186,Anti-acetyl-Histone H4 (Lys77) Antibody

    产品名称：Anti-acetyl-Histone H4 (Lys77) Antibody
    产品型号：ABE186
    Anti-acetyl-Histone H4 (Lys77) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl-Histone H4 (Lys77) also known as H4K77Ac, Histone H4 (acetyl K77) & has been validated in WB, DB.

    merck millipore,默克密理博,ABE186,Anti-acetyl-Histone H4 (Lys77) Antibody

  • 产品介绍
  • merck millipore,默克密理博,ABE186,Anti-acetyl-Histone H4 (Lys77) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbAffinity PurifiedPolyclonal Antibody
    描述
    产品目录编号 ABE186
    描述 Anti-acetyl-Histone H4 (Lys77) Antibody
    Alternate Names
    • Histone H4
    背景信息 Histones are nuclear proteins that form octameric structures which bind DNA to form units of chromatin called nucleosomes. The family of histones—H2A, H2B, H3, and H4—are key players in gene regulation. They undergo a number of post-translational modifications (PTM) in response to various stimuli. Acetylation is a reversible PTM that involves the transfer of acetyl groups to N-terminal lysine (K) residues by the family of histone acetyltransferase enzymes, including GNAT, Gcn5, and p300/CBP. Histone acetylation reduces the electrostatic attractions between DNA and histones, which destabilizes chromatin structure and provide chromatin remodeling and transcriptional complexes with access to DNA, potentially resulting in increased gene transcription.
    产品信息
    格式 Affinity Purified
    控制
    • Untreated and sodium butyrate treated HeLa acid extract, and recombinant Histone H4 protein
    演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
    应用
    应用 Anti-acetyl-Histone H4 (Lys77) Antibody is a Rabbit Polyclonal Antibody for detection of acetyl-Histone H4 (Lys77) also known as H4K77Ac, Histone H4 (acetyl K77) & has been validated in WB, DB.
    主要应用
    • Western Blotting
    应用说明 Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with Anti-acetyl-Histone H4 (Lys77) (1:320 dilution).
    生物信息
    免疫原品种 KLH-conjugated linear peptide corresponding to yeast Histone H4 acetylated at Lys77.
    表位 Acetylated Lys77
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 This antibody recognizes Histone H4 acetylated at Lys77.
    品种反应性 MouseHuman
    Species Reactivity Note Demonstrated to react with Human and Mouse. Predicted to react with Yeast based on immunogen design. Broad species reactivity is expected based on similar sequence homology.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NP_009563
    基因符号
    • HHF2
    • HHF1
    纯化方法 Affinity purified
    UniProt编号
    • P02309
    产品使用声明
    质量保证 Evaluated by Western Blot in untreated and sodium butyrate treated HeLa acid extract, and recombinant Histone H4 protein.

    Western Blot Analysis: A 1:320 dilution of this antibody detected Histone H4 acetylated at Lys77 in 10 µg of untreated and sodium butyrate treated HeLa acid extract, and recombinant Histone H4 protein.
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Stable for 1 year at 2-8°C from date of receipt.
    包装信息
    数量 200 µL

    merck millipore,默克密理博,ABE186,Anti-acetyl-Histone H4 (Lys77) Antibody

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