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品种反应性 主要应用 宿主 格式 抗体类型 Chp, H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABE114 描述 Anti-PRDM5 Antibody Alternate Names - PR domain-containing protein 5
- PR domain zinc finger protein 5
背景信息 PRDM5 is a member of the PR-domain containing family of tumor suppressors. PRDM5 activates histone methyltransferase G9a and class I histone deacetylases to regulate transcription. PRDM5 typically functions as a transcriptional repressor but can also be an activator for endogenous target genes. PRDM5 has often been found to be silenced in human breast, ovarian and liver cancers and and is a candidate biomarker for certain cancers, such as gastrointestinal cancer. Additional studies have also linked the loss of PRDM5 function to the development and pathogenesis of cervical cancer. 产品信息 格式 Affinity Purified 控制 - PC3 cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-PRDM5 Antibody (Rabbit Polyclonal Antibody) validated in WB to detect PRDM5 also known as PR domain-containing protein 5. 主要应用 - Western Blotting
应用说明 Western Blot Analysis:1 µg/mL from a representative lot detected PRDM5 on 10 µg of HeLa cell lysate and HeLa nuclear extract. 生物信息 免疫原品种 Linear peptide corresponding to human PRDM5. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 ChimpanzeeHuman Species Reactivity Note Demonstrated to react with Human. Predicted to react with Chimpanzee based on 100% sequence homology. 抗体类型 Polyclonal Antibody Entrez基因编号 - NP_061169
Entrez基因汇总 The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. [provided by RefSeq]. 基因符号 - PFM2
- PRDM5
纯化方法 Affinity purified UniProt编号 - Q9NQX1
UniProt汇总 FUNCTION: Sequence-specific DNA-binding transcription factor. Represses transcription at least in part by recruitment of the histone methyltransferase EHMT2/G9A and histone deacetylases such as HDAC1. Regulates hematopoiesis-associated protein-coding and microRNA (miRNA) genes.
SUBUNIT STRUCTURE: Interacts with EHMT2/G9A, GFI1 and HDAC1.
SUBCELLULAR LOCATION: Nucleus
SEQUENCE SIMILARITIES: Contains 16 C2H2-type zinc fingers.
Contains 1 SET domain.产品使用声明 质量保证 Evaluated by Western Blot in PC3 cell lysate.
Western Blot Analysis: 1 µg/mL of this antibody detected PRDM5 on 10 µg of PC3 cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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