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品种反应性 主要应用 宿主 格式 抗体类型 M, H ICC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD32 描述 Anti-B-myb Antibody Alternate Names - Myb-like protein 2
- Myb-related protein B
- B-Myb
背景信息 Myb is a transcriptional activator and a proto-oncogene protein that specifically recognizes the sequence 5'-YAAC[GT]G-3'. B-myb plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. Studies suggest that it also may play a role in tumorigenesis. 产品信息 格式 Affinity Purified 控制 - Mouse embryonic stem cell lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Use Anti-B-myb Antibody (Rabbit Polyclonal Antibody) validated in WB, ICC to detect B-myb also known as Myb-related protein B. 主要应用 - Immunocytochemistry
- Western Blotting
应用说明 Immunocytochemistry Analysis: A 1:500 dilution from a representative lot detected B-myb in mouse embryonic stem cells. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human B-myb at the HTH myb-type 1 domain. 表位 HTH myb-type 1 domain 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes b-myb at the HTH myb-type 1 domain. 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human and Mouse.
Other homologies: Rat and Bovine (91% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_002457
Entrez基因汇总 The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Transcript variants may exist for this gene, but their full-length natures have not been determined. [provided by RefSeq, Jul 2008]. 基因符号 - BMYB
- MYBL2
纯化方法 Affinity Purified UniProt编号 - P10244
UniProt汇总 FUNCTION: Transcription factor involved in the regulation of cell survival, proliferation, and differentiation. Transactivates the expression of the CLU gene.
SUBUNIT STRUCTURE: Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL22.
SUBCELLULAR LOCATION: Nucleus.
PTM: Phosphorylated by cyclin A/CDK2 during S-phase. Phosphorylation at Thr-520 is probably involved in transcriptional activity.
SEQUENCE SIMLARITIES: Contains 3 HTH myb-type DNA-binding domains.产品使用声明 质量保证 Evaluated by Western Blot in mouse embryonic stem cell lysate.
Western Blot Analysis: 0.2 µg/mL of this antibody detected B-myb on 10 µg of mouse embryonic stem cell lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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