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品种反应性 主要应用 宿主 格式 抗体类型 H WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABD26 描述 Anti-SLAM (CD150) Antibody Alternate Names - CD_antigen=CD150
- Signaling lymphocytic activation molecule
- CDw150
- IPO-3
背景信息 Signaling lymphocyte activation molecule (SLAM) family member 1 (also known as CD150) is a self-ligand cell surface glycoprotein expressed on T cells, B cells, macrophages, and dendritic cells. CD150 plays an important role in adhesion and signaling between T cells and antigen-presenting cells (APCs), and it is involved in two major immune functions: costimulation of T-cell proliferation and augmentation of interferon response. CD150 is the prototypical member of a growing family of glycoprotein receptors on hematopoietic stem cells known as the SLAM family, which includes CD229, CD84, CD244, SF2000/Ly108, SF2001, and 19A(CRACC). Members of this family are defined by one or more cytoplasmic tyrosine motifs. 产品信息 格式 Affinity Purified 控制 - Human spleen tissue lysate
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-SLAM (CD150) Antibody detects level of SLAM (CD150) & has been published & validated for use in WB. 主要应用 - Western Blotting
生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to the potential SH2 binding domain of human SLAM. 表位 Potential SH2 binding domain. 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes the potential SH2 binding domain of SLAM. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human.
Other homologies: Rat and Mouse (75% sequence homology).抗体类型 Polyclonal Antibody Entrez基因编号 - NP_003028
基因符号 - SLAM
- SLAMF1
纯化方法 Affinity Purified UniProt编号 - Q13291
UniProt汇总 FUNCTION: High-affinity self-ligand important in bidirectional T-cell to B-cell stimulation. SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
SUBUNIT STRUCTURE: Interacts (via cytoplasmic domain) with SH2D1A, and with PTPN11. Interacts with INPP5D/SHIP1. Binds to Measles virus H protein and acts as a receptor for this virus.
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note: Present on the surface of B-cells and T-cells.产品使用声明 质量保证 Evaluated by Western Blot in human spleen tissue lysate.
Western Blot Analysis: 5 µg/mL of this antibody detected SLAM in human spleen tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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