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品种反应性 主要应用 宿主 格式 抗体类型 H IHC, WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC844 描述 Anti-IEX1 Antibody Alternate Names - IEX1
- Radiation-inducible immediate-early gene IEX-1
- Differentiation-dependent gene 2 protein
- Protein DIF-2
- Immediate early protein GLY96
- Immediate early response 3 protein
- PACAP-responsive gene 1 protein
- Protein PRG1
背景信息 Radiation-inducible immediate-early gene IEX-1, also known as Differentiation-dependent gene 2 protein (DIF-2) or PACAP-responsive gene 1 protein (Protein PRG1), and encoded by the gene name IER3 or DIF2 or IEX1 or PRG1, is a stress inducible gene that is induced by ionizing radiation, ultraviolet radiation, and a variety of growth factors, i.e., FAS and TNF-α. IEX1 is widely expressed in epithelial and endocrine tissues, as well as in vascular endothelium. IEX1 plays an important role in the regulation of cellular growth, cell death and oncogenesis and is precisely regulated by multiple transcription factors such as p53, NF-κB/rel, Sp1 and c-Myc, to ensure rapid and transient expression of IEX1 in cells under a variety of stress conditions. IEX1 is expressed as both a longer form (IEX1L) and a splice variant, designated IEX1S. It is localized to the nucleus and perinuclear region. Overexpression of IEX1 facilitates apoptosis and cell cycle progression, whereas disruption of IEX1 expression is associated with decreases in both apoptosis and cell cycle progression. 产品信息 格式 Affinity Purified 演示 Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide. 应用 应用 Anti-IEX1 Antibody is an antibody against IEX1 for use in western blotting, IHC & immunofluorescence. 主要应用 - Immunohistochemistry
- Western Blotting
应用说明 Immunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected IEX1 in human liver tissue.
Immunofluorescence Analysis: 20 μg/mL from a representative lot detected IEX1 in human brain cells.生物信息 免疫原品种 KLH-conjugated synthetic peptide corresponding to the center region of human IEX1. 表位 Center region 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 品种反应性 Human 抗体类型 Polyclonal Antibody 基因符号 - PRG1
- IER3
- DIF2
- IEX1
纯化方法 Affinity UniProt编号 - P46695
产品使用声明 质量保证 Evaluated by Western Blotting in human brain tissue lysate.
Western Blotting Analysis: 4 μg/mL of this antibody detected IEX1 in human brain tissue lysate.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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