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merck millipore,默克密理博,FCMAB341F,Milli-Mark Anti-Reelin-FITC, a.a. 164-496 Antibody, clone G10
产品名称：Milli-Mark Anti-Reelin-FITC, a.a. 164-496 Antibody, clone G10
产品型号：FCMAB341F
Detect Milli-Mark Reelin-FITC, a.a. 164-496 using this Milli-Mark Anti-Reelin-FITC, a.a. 164-496 Antibody, clone G10 validated for use in Flow Cytometry.
merck millipore,默克密理博,FCMAB341F,Milli-Mark Anti-Reelin-FITC, a.a. 164-496 Antibody, clone G10
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 M, H FC M FITC Monoclonal Antibody 描述 产品目录编号 FCMAB341F 商名 - Milli-Mark
描述 Milli-Mark® Anti-Reelin-FITC, a.a. 164-496 Antibody, clone G10 背景信息 The highly layered structure of the cerebral cortex is established through the pattern of neuronal cell migrations. The first step is the creation of the primordial layer, the preplate, consisting of radial glial cells and the earliest generated neurons. Among these neurons are the Cajal-Retzius neurons. In the next step, the preplate splits into a superficial (marginal) zone, where the Cajal-Retzius neurons reside, and a deep subplate wherein the neurons form. Neurons migrating from the subplate form the cortical plate. This migration takes place on the radial glial fibers.
The reeler mutant in mouse displays an abnormal pattern of cell migration throughout the cerebral and cerebellar cortices. The preplate forms normally, and the neurons differentiate at the correct times in the ventricular zone. However, instead of forming the normal "inside-out" arrangement of neurons in the cortical plate, the older neurons are found furthest from the ventricular zone, while the younger neurons do not migrate far at all. The reeler cerebral cortex is inverted from that of the wild type mouse.
The defect of the reeler mice appears to be in the production of an extracellular matrix protein by the Cajal-Retzius cells (D'Arcangelo et al., 1995, Nature 374:719-723.; Ogawa et al., 1995 Neuron 14:899-912.) This 388kDa protein is made by wild-type mice but not by the reeler mutants. It is thought that this Reelin protein is crucial for positioning the migrating neuron within the cortical plate (Figure 1). In the absence of Reelin, the migrating neuron would be "lost," and the cortical plate would be abnormal. We do not yet know the mechanisms by which Reelin informs the cells as to their position, how the cell responds to Reelin, and why the absence of reelin should give an "inverted" plate. However, the identification of the protein encoded by the reeler gene should allow us to begin these studies.产品信息 格式 FITC 控制 - A431 cells
演示 Purified mouse monoclonal IgG1 conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA. 应用 应用 Detect Milli-Mark Reelin-FITC, a.a. 164-496 using this Milli-Mark Anti-Reelin-FITC, a.a. 164-496 Antibody, clone G10 validated for use in Flow Cytometry. 主要应用 - Flow Cytometry
生物信息 免疫原品种 Recombinant reelin amino acids 164-496 表位 a.a. 164-496 mreelin 克隆 G10 宿主 Mouse 同种型 IgG1κ 品种反应性 MouseHuman Species Reactivity Note Demonstrated to react with Human. Predicted to react with Mouse and Rat based on 100% sequence homology. 抗体类型 Monoclonal Antibody Entrez基因编号 - NP_005036.2
基因符号 - EC 3.4.21.-
- RELN
- reelin
- RL
纯化方法 Protein A purified UniProt编号 - P78509
产品使用声明 质量保证 Evaluated by flow cytometry using A431 cells 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt. 包装信息 数量 100 tests
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