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品种反应性 主要应用 宿主 格式 抗体类型 H IHC Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 ABC50 描述 Anti-Noxa Antibody Alternate Names - Protein Noxa
- Phorbol-12-myristate-13-acetate-induced protein 1
- PMA-induced protein 1
- Immediate-early-response protein APR
背景信息 Noxa, a BH3-only protein, is induced in response to apoptotic stimuli such as DNA damage, hypoxia, and proteasome inhibition and required for apoptosis in response to glucose stress. Noxa is constitutively expressed in proliferating hematopoietic lineage cells. The expression of Noxa involves direct activation of its promotor by p53 and studies demonstated that the blocking of endogenous Noxa induction results in the suppression of apoptosis thereby suggesting that Noxa represents a mediator of p53 dependent apoptosis. 产品信息 格式 Affinity Purified 控制 - Osteoblasts in human bone tissue
演示 Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. 应用 应用 Anti-Noxa Antibody is an antibody against Noxa for use in IH. 主要应用 - Immunohistochemistry
应用说明 Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Noxa in neurons in normal human brain tissue. 生物信息 免疫原品种 KLH-conjugated linear peptide corresponding to human Noxa at the N-terminus. 表位 N-terminus 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 This antibody recognizes Noxa at the N-terminus. 品种反应性 Human Species Reactivity Note Demonstrated to react with Human.
Predicted to react with Orangutan based on 100% sequence homology.抗体类型 Polyclonal Antibody Entrez基因编号 - NP_066950
基因符号 - NOXA
- PMAIP1
纯化方法 Affinity purified UniProt编号 - Q13794
UniProt汇总 FUNCTION: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
SUBUNIT STRUCTURE: Interacts with MCL1 and BAX.
SUBCELLULAR LOCATION: Mitochondrion
TISSUE SPECIFICITY: Highly expressed in adult T-cell leukemia cell line.
INDUCTION: Up-regulated by p53/TP53, phorbol esters, double-stranded RNA, IFNB1/IFN-beta and viruses.
DOMAIN: The BH3 motif is essential for pro-apoptotic activity.
SEQUENCE SIMILARITIES: Belongs to the PMAIP1 family.产品使用声明 质量保证 Evaluated by Immunohistochemistry in osteoblasts in human bone tissue.
Immunohistochemistry Analysis: A 1:200 dilution of this antibody detected Noxa in osteoblasts in human bone tissue.使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Stable for 1 year at 2-8°C from date of receipt. 包装信息 数量 100 µg
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