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merck millipore,默克密理博,AB9880,Anti-Huntingtin-Interacting Protein (HIP1) Antibody
产品名称：Anti-Huntingtin-Interacting Protein (HIP1) Antibody
产品型号：AB9880
Anti-Huntingtin-Interacting Protein (HIP1) Antibody detects level of Huntingtin-Interacting Protein (HIP1) & has been published & validated for use in WB.
merck millipore,默克密理博,AB9880,Anti-Huntingtin-Interacting Protein (HIP1) Antibody
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R, H WB Rb Purified Polyclonal Antibody 描述 产品目录编号 AB9880 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Huntingtin-Interacting Protein (HIP1) Antibody Alternate Names - HIP1
产品信息 格式 Purified 演示 Liquid 应用 应用 Anti-Huntingtin-Interacting Protein (HIP1) Antibody detects level of Huntingtin-Interacting Protein (HIP1) & has been published & validated for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:500-1:1,000 on P2 microsomal fraction from embryonic rat brain.
Optimal working dilutions must be determined by end user.生物信息 免疫原品种 Synthetic peptide 宿主 Rabbit 特异性 Huntingtin-interacting protein 1 (HIP1). By Western blot the antibody recognizes a band at ~116 kDa on P2 microsomal fraction from embryonic rat brain. 品种反应性 RatHuman 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_005338.4
Entrez基因汇总 The product of this gene is a membrane-associated protein that colocalizes with huntingtin. This protein has similarities to cytoskeleton proteins and its interaction with huntingtin is thought to play a functional role in the cell filament network. Loss of normal huntingtin-HIP1 interaction in Huntington disease may contribute to a defect in membrane-cytoskeletal integrity in the brain. This gene could help in the understanding of the normal function of huntingtin and also the pathogenesis of Huntington disease. It also has been implicated in the pathogenesis of hematopoietic malignancies. An alternative splice variant of this gene has been described but its full length sequence has not been determined. 基因符号 - ILWEQ
- HIP1
- HIP-I
- MGC126506
UniProt编号 - O00291
UniProt汇总 FUNCTION: SwissProt: O00291 # May play a functional role in the cell filament networks.
SIZE: 1030 amino acids; 115442 Da
SUBUNIT: Binds huntingtin. This interaction is restricted to the brain. Binds to Hippi.
SUBCELLULAR LOCATION: Intracytoplasmic membrane.
TISSUE SPECIFICITY: Ubiquitously expressed with the highest level in brain.
SIMILARITY: SwissProt: O00291 ## Belongs to the SLA2 family. & Contains 1 ENTH (epsin N-terminal homology) domain. & Contains 1 I/LWEQ domain.
MISCELLANEOUS: The affinity of the huntingtin protein-HIP1 interaction is inversely correlated to the length of the polyglutamine tract added to the huntingtin protein in Huntington disease.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles. 包装信息 数量 100 µL
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