merck millipore,默克密理博,AB9864R,Anti-NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal

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merck millipore,默克密理博,AB9864R,Anti-NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal
产品名称：Anti-NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal
产品型号：AB9864R
Anti-NMDAR1 Antibody, clone 1.17.2.6 detects level of NMDAR1 & has been published & validated for use in WB, IH.

merck millipore,默克密理博,AB9864R,Anti-NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal

产品介绍

merck millipore,默克密理博,AB9864R,Anti-NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal

重要规格表

品种反应性	主要应用	宿主	格式	抗体类型
H, R, M	IHC, WB	Rb	Unconjugated	Monoclonal Antibody

描述
产品目录编号	AB9864R
描述	Anti-NMDAR1 Antibody, clone 1.17.2.6, rabbit monoclonal
Alternate Names	glutamate receptor, ionotropic, N-methyl D-aspartate 1 N-methyl-D-aspartate receptor channel, subunit zeta-1 N-methyl-D-aspartate receptor subunit NR1 NMDA receptor 1 glutamate [NMDA] receptor subunit zeta 1
背景信息	N-methyl-D-aspartate receptor subunit NR1 (NMDAR1) is a multi-pass membrane protein belonging to the glutamate-gated ion channel family and is one of two subunits comprising the tetrameric protein NMDAR localized throughout the brain at excitatory synapses. NMDAR1 is mediated by glycine and is a critical component to excitotoxicity, learning, memory acquisition, synaptic plasticity, and synaptogenesis. It also plays a regulatory role for neuronal functions involving glutamate neurotransmission and the targeting of NMDA receptors on the cell surface. As a glutamate-gated ion channel, NMDAR1 is highly calcium permeable and possesses sensitivity to magnesium in a voltage-dependent manner.

产品信息
格式	Unconjugated
控制	Rat brain tissue lysate
演示	Purified rabbit monoclonal IgG in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide and 40% Glycerol.

应用
应用	Anti-NMDAR1 Antibody, clone 1.17.2.6 detects level of NMDAR1 & has been published & validated for use in WB, IH.
主要应用	Immunohistochemistry Western Blotting
应用说明	Western Blot Analysis: 0.1 µg/mL of this antibody from a previous lot detected NMDAR1 on 10 µg of mouse microsomal brain tissue lysate. Immunohistochemistry Analysis: 1:250 dilution of this antibody from a previous lot detected NMDAR1 in rat cerebellum tissue.

生物信息
免疫原品种	Linear peptide corresponding to human NMDAR1.
表位	Recognizes NMDAR1 at the C-terminus
克隆	clone 1.17.2.6
浓缩	Please refer to the Certificate of Analysis for the lot-specific concentration.
宿主	Rabbit
同种型	IgG
品种反应性	HumanRatMouse
Species Reactivity Note	Demonstrated to react with rat and mouse. Predicted to react with human based on 100% sequence homology.
抗体类型	Monoclonal Antibody
Entrez基因编号	NP_000823
Entrez基因汇总	The protein encoded by this gene is a critical subunit of N-methyl-D-aspartate receptors, members of the glutamate receptor channel superfamily which are heteromeric protein complexes with multiple subunits arranged to form a ligand-gated ion channel. These subunits play a key role in the plasticity of synapses, which is believed to underlie memory and learning. Cell-specific factors are thought to control expression of different isoforms, possibly contributing to the functional diversity of the subunits. Alternatively spliced transcript variants have been described. [provided by RefSeq].
基因符号	AG317 GRIN1 NR1 Glutamate NMDAR NMDA1 NMDAR1
纯化方法	Protein A
UniProt编号	Q05586
UniProt汇总	FUNCTION: NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. This protein plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. It mediates neuronal functions in glutamate neurotransmission. Is involved in the cell surface targeting of NMDA receptors (By similarity). SUBUNIT STRUCTURE: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B); disulfide-linked. Found in a complex with GRIN2A or GRIN2B, GRIN3A or GRIN3B and PPP2CB. Interacts with DLG4 and MPDZ (By similarity). Interacts with LRFN1 and LRFN2 (By similarity). SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein By similarity. Cell junction › synapse › postsynaptic cell membrane (By similarity). Cell junction › synapse › postsynaptic cell membrane › postsynaptic density (By similarity). Note: Enriched in post-synaptic plasma membrane and post-synaptic densities (By similarity). PTM: NMDA is probably regulated by C-terminal phosphorylation of an isoform of NR1 by PKC. Dephosphorylated on Ser-897 probably by protein phosphatase 2A (PPP2CB). Its phosphorylated state is influenced by the formation of the NMDAR-PPP2CB complex and the NMDAR channel activity (By similarity). SEQUENCE SIMILARITIES: Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR1/GRIN1 subfamily. [View classification]

产品使用声明
质量保证	Evaluated by Western Blot in rat brain tissue lysate. Western Blot Analysis: 0.1 µg/mL of this antibody detected NMDAR1 on 10 µg of rat brain tissue lysate.
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.

储存和货运信息

存储条件

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.