merck millipore,默克密理博,AB5974,Anti-Dishevelled-3 Antibody

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Merck Millipore 默克密理愽

品种反应性	主要应用	宿主	格式	抗体类型
M, H	WB	Rb	Purified	Polyclonal Antibody

描述
产品目录编号	AB5974
品牌系列	Chemicon®
商名	Chemicon
描述	Anti-Dishevelled-3 Antibody
Alternate Names	DSH Homolog 3 DVL3
背景信息	DVL3 is a member of multigene family that also contains DVL1 and DVL2. The vertebrate dishevelled proteins have approximately 40% amino acid sequence similarity with Drosophila dsh. DVL3 encodes a predicted 716 amino acid polypeptide that shows 74% nucleotide similarity with human DVL1. Similarity is particularly high in the N-terminal region and there is more divergence in the C-terminal regions.

产品信息
格式	Purified
控制	A-431 cell lysate
演示	Partially purified immunoglobulin. Liquid in PBS, pH 7.4, containing 0.01M sodium azide.

应用
应用	Anti-Dishevelled-3 Antibody detects level of Dishevelled-3 & has been published & validated for use in WB.
主要应用	Western Blotting
应用说明	Western blot: 1:1,000 using ECL. The antibody reacts with a protein of ~90 kDa. Weak reactivity is seen to dvl-1 and dvl-2 due to protein-protein interaction, and is not abolished following peptide pre-adsorption. Dilute antibody in 50 mM PBS, pH 7.4 containing 1.5% sodium chloride and 1% normal animal serum (same species as the host of the secondary antibody). Optimal working dilutions must be determined by end user.

生物信息
免疫原品种	Synthetic peptide corresponding to amino acids 582-596 of human and mouse disheveiled-3 protein.
宿主	Rabbit
特异性	Disheveiled-3 protein (dvl-3). Pre-adsorption of the antibody with the immunogen peptide completely abolishes its reactivity by Western blot against disheveiled-3 protein.
品种反应性	MouseHuman
抗体类型	Polyclonal Antibody
Entrez基因编号	NM_004423.3
Entrez基因汇总	This gene is a member of a multi-gene family which shares strong similarity with the Drosophila dishevelled gene, dsh. The Drosophila dishevelled gene encodes a cytoplasmic phosphoprotein that regulates cell proliferation.
基因符号	Dishevelled-3 DVL3 KIAA0208
UniProt编号	Q92997
UniProt汇总	FUNCTION: SwissProt: Q92997 # May play a role in the signal transduction pathway mediated by multiple Wnt genes. SIZE: 716 amino acids; 78055 Da SUBUNIT: Interacts through its PDZ domain with the C-terminal regions of VANGL1 and VANGL2 (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). SIMILARITY: SwissProt: Q92997 ## Belongs to the DSH family. & Contains 1 DEP domain. & Contains 1 DIX domain. & Contains 1 PDZ (DHR) domain.

产品使用声明
使用声明	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存和货运信息
存储条件	Maintain at -20°C in undiluted aliquots (not less than 10 mL) for up to 6 months. Avoid repeated freeze/thaw cycles. The use of high quality antiserum-grade plastic or glass is recommended.

包装信息
数量	50 µL

merck millipore,默克密理博,AB5974,Anti-Dishevelled-3 Antibody

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