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merck millipore,默克密理博,AB5849,Anti-Glutamate Receptor 1 Antibody, phosphoSer 845
产品名称：Anti-Glutamate Receptor 1 Antibody, phosphoSer 845
产品型号：AB5849
Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 is an antibody against Glutamate Receptor 1 for use in WB.
merck millipore,默克密理博,AB5849,Anti-Glutamate Receptor 1 Antibody, phosphoSer 845
- 产品介绍
重要规格表
品种反应性 主要应用 宿主 格式 抗体类型 R WB Rb Affinity Purified Polyclonal Antibody 描述 产品目录编号 AB5849 品牌系列 Chemicon®
商名 - Chemicon
描述 Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 Alternate Names - GluR1
背景信息 Glutamate receptor 1 (AMPA) belongs to the glutamate-gated ion channel and binds AMPA, glutamate and kainate. L-Glutamate is the major excitatory neurotransmitter in the mammalian CNS, acting through both ligand gated ion channels (ionotropic receptors; composed of subunits GluR1-4) and G-protein coupled (metabotropic) receptors. The AMPA glutamate receptors mediate fast synaptic transmission in the CNS. 产品信息 格式 Affinity Purified 控制 - Human brain tissue
演示 Affinity Purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, with 150 mM NaCl, 100 μg/mL BSA and 50% glycerol. 应用 应用 Anti-Glutamate Receptor 1 Antibody, phosphoSer 845 is an antibody against Glutamate Receptor 1 for use in WB. 主要应用 - Western Blotting
应用说明 Western blot: 1:1,000
Optimal working dilutions must be determined by the end user.生物信息 免疫原品种 Synthetic peptide corresponding to amino acids surrounding the phosphoSer845 of rat GluR1. 表位 phosphoSer 845 浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration. 宿主 Rabbit 特异性 Recognizes Glutamate Receptor 1 [GluR1], phosphoSe845. The antibody recognizes a protein of 100 kDa corresponding to GluR1 phosphorylated at Ser845. 品种反应性 Rat 抗体类型 Polyclonal Antibody Entrez基因编号 - NM_000827.2
Entrez基因汇总 Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. This gene belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. 基因符号 - GluR-K1
- GLURA
- HBGR1
- GluR-A
- GluR-1
- GLUH1
- GLUR1
- MGC133252
- GRIA1
修改 - Phosphorylation
纯化方法 Immunoaffinity purified UniProt编号 - P42261
UniProt汇总 FUNCTION: SwissProt: P42261 # Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
SIZE: 906 amino acids; 101506 Da
SUBUNIT: Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2 and RASGRF2 (By similarity).
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Note=Interaction with CACNG2 promotes cell surface expression (By similarity).
TISSUE SPECIFICITY: Widely expressed in brain.
PTM: Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity).
SIMILARITY: SwissProt: P42261 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
MISCELLANEOUS: The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds AMPA (quisqualate) > glutamate > kainate.产品使用声明 使用声明 - Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
储存和货运信息 存储条件 Maintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. 包装信息 数量 150 µL
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