merck millipore,默克密理愽
  • merck millipore,默克密理博,AB5699,Anti-Cysteine-rich Motor Neuron 1 Antibody

  • merck millipore,默克密理博,AB5699,Anti-Cysteine-rich Motor Neuron 1 Antibody

    产品名称：Anti-Cysteine-rich Motor Neuron 1 Antibody
    产品型号：AB5699
    Anti-Cysteine-rich Motor Neuron 1 Antibody detects level of Cysteine-rich Motor Neuron 1 & has been published & validated for use in IP & WB.

    merck millipore,默克密理博,AB5699,Anti-Cysteine-rich Motor Neuron 1 Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5699,Anti-Cysteine-rich Motor Neuron 1 Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    M, HWBRbSerumPolyclonal Antibody
    描述
    产品目录编号 AB5699
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Cysteine-rich Motor Neuron 1 Antibody
    Alternate Names
    • CRIM1
    产品信息
    格式 Serum
    演示 Rabbit serum. Liquid.
    应用
    应用 Anti-Cysteine-rich Motor Neuron 1 Antibody detects level of Cysteine-rich Motor Neuron 1 & has been published & validated for use in IP & WB.
    主要应用
    • Western Blotting
    应用说明 Western blot: 1:1,000 using ECL. The antibody reacts with proteins of ~120 kDa. Preferred gel percentage is 7.5%. Suggested blocking buffer is PBS containing 5% non-fat milk. Suggested dilution buffer is PBS containing 1% non-fat milk.

    Immunoprecipitation: 5 μL to 1 mL of cell extract. Preferred tissue/cell lysis buffer is RIPA. Suggested incubation time is 2-4 hours. Suggested capture agent is Protein A.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Recombinant protein from the cytoplasmic tail of mouse Crim1.
    宿主 Rabbit
    特异性 Crim1

    SUBCELLULAR LOCALIZATION: Intracellular and Membrane associated.
    品种反应性 MouseHuman
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_016441.1
    Entrez基因汇总 Motor neurons are among the earliest neurons to appear after the commencement of cell patterning and the beginning of cell differentiation. Differentiation occurs in a ventral-to-dorsal gradient and is mediated, at least in part, by the concentration of ventrally expressed sonic hedgehog protein (SHH; MIM 600725). Dorsally expressed factors, such as members of the bone morphogenic protein (e.g., BMP4; MIM 112262) and transforming growth factor-beta (e.g., TGFB1; MIM 190180) families, can repress the induction of these neurons. CRIM1 may interact with growth factors implicated in motor neuron differentiation and survival (Kolle et al., 2000 [PubMed 10642437]).[supplied by OMIM]
    基因符号
    • S52
    • CRIM1
    • CRIM-1
    • MGC138194
    UniProt编号
    • Q9NZV1
    UniProt汇总 FUNCTION: SwissProt: Q9NZV1 # May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface.
    SIZE: 1036 amino acids; 113738 Da
    SUBUNIT: Interacts with BMP4 and BMP7.
    SUBCELLULAR LOCATION: Processed cysteine-rich motor neuron 1 protein: Secreted. & Cell membrane; Single-pass type I membrane protein.
    TISSUE SPECIFICITY: Expressed in pancreas, kidney, skeletal muscle, lung, placenta, brain, heart, spleen, liver and small intestine. Expressed in blood vessels (at protein level).
    PTM: N-glycosylated.
    SIMILARITY: SwissProt: Q9NZV1 ## Contains 4 antistasin-like domains. & Contains 1 IGFBP N-terminal domain. & Contains 6 VWFC domains.
    产品使用声明
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20°C in undiluted aliquots for up to 12 months after date of receipt. Avoid repeated freeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5699,Anti-Cysteine-rich Motor Neuron 1 Antibody

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