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  • merck millipore,默克密理博,AB5622,Anti-Microtubule-Associated Protein 2 (MAP2) Antibody

  • merck millipore,默克密理博,AB5622,Anti-Microtubule-Associated Protein 2 (MAP2) Antibody

    产品名称：Anti-Microtubule-Associated Protein 2 (MAP2) Antibody
    产品型号：AB5622
    Detect Microtubule-Associated Protein 2 (MAP2) using this Anti-Microtubule-Associated Protein 2 (MAP2) Antibody validated for use in ELISA, IC, IH, IH(P) & WB.

    merck millipore,默克密理博,AB5622,Anti-Microtubule-Associated Protein 2 (MAP2) Antibody

  • 产品介绍
  • merck millipore,默克密理博,AB5622,Anti-Microtubule-Associated Protein 2 (MAP2) Antibody

    重要规格表

    品种反应性 主要应用 宿主 格式 抗体类型
    R, H, MWB, ELISA, ICC, IHCRbPurifiedPolyclonal Antibody
    描述
    产品目录编号 AB5622
    品牌系列 Chemicon®
    商名
    • Chemicon
    描述 Anti-Microtubule-Associated Protein 2 (MAP2) Antibody
    Alternate Names
    • microtubule-associated protein 2
    背景信息 The microtubule-associated protein 2 (MAP2) is an abundant neuronal cytoskeletal protein that binds to tubulin and stabilizes microtubules. (Herzog and Weber, 1978). MAP2 is essential for the development and maitenance of neuronal morphology (Matus, 1991). In neurons MAP2 occurs as three primary isoforms, the high molecular weight MAP2a, MAP2b, and the low molecular weight MAP2c, that result from alternative splicing of the MAP2 gene (Chung et al., 1996). The low molecular weight isoform, MAP2c, is expressed in developing brain and is down-regulated during brain maturation, whereas the high molecular weight MAP2b is expressed in both developing and adult brain. The MAP2a appears only after brain maturation (Tucker, 1990). All these forms bind to microtubules through a domain near the carboxyl terminus that contains either three or four similar repeats of a 31-amino-acid motif (Lewis et al., 1988). MAP2 together with MAP4 and tau proteins belong to the family of thermostable proteins associated with microtubules.
    产品信息
    格式 Purified
    控制
    • Human brain tissue or human glioblastoma T98G cells
    演示 Purified rabbit polyclonal in buffer containing PBS with 0.1% sodium azide as a preservative.
    应用
    应用 Detect Microtubule-Associated Protein 2 (MAP2) using this Anti-Microtubule-Associated Protein 2 (MAP2) Antibody validated for use in ELISA, IC, IH, IH(P) & WB.
    主要应用
    • Western Blotting
    • ELISA
    • Immunocytochemistry
    • Immunohistochemistry
    应用说明 Immunocytochemistry:
    1:1,000 dilution of a previous lot was used on primary neurons.

    Immunohistochemistry:
    1:1,000 dilution on 4% paraformaldehyde / PBS fixed tissue sections.

    Immunoblot:
    1:2,000 dilution was used on a previous lot. Recognizes MAP2A (280-300kDa, and MAP2B (270-280KDa), and to a lesser extent MAP2C (70kDa) and MAP2D (70-75kDa).

    ELISA:
    greater than or equal to1:2,000 dilution of a previous lot was used.

    Optimal working dilutions must be determined by the end user.
    生物信息
    免疫原品种 Purified Microtubule-associated protein from rat brain.
    浓缩 Please refer to the Certificate of Analysis for the lot-specific concentration.
    宿主 Rabbit
    特异性 Specific for Microtubule-associated protein 2 (MAP2). The antibody recognizes all MAP2 isoforms (MAP2A, MAP2B, MAP2C and MAP2D). It shows greatest immunoreactivity with the HMW-MAP2 (MAP2A and MAP2B).
    品种反应性 RatHumanMouse
    Species Reactivity Note Human, mouse and rat. Reactivity with other species has not been determined.
    抗体类型 Polyclonal Antibody
    Entrez基因编号
    • NM_001039538.1
    Entrez基因汇总 This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isforms have been described.
    基因符号
    • MAP2A
    • MAP2
    • MAP2B
    • MAP-2
    • MAP2C
    • DKFZp686I2148
    纯化方法 Ammonium sulfate precipitation
    UniProt编号
    • P11137
    UniProt汇总 FUNCTION: SwissProt: P11137 # The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
    SIZE: 1827 amino acids; 199539 Da
    PTM: MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.
    SIMILARITY: SwissProt: P11137 ## Contains 3 Tau/MAP repeats.
    产品使用声明
    质量保证 Immunohistochemistry(paraffin) Analysis:
    MAP2 (cat. # AB5622) staining on Normal Cerebellum. Tissue pretreated with Citrate, pH 6.0. This lot of antibody was diluted to 1:500, using IHC-Select® Detection with HRP-DAB. Immunoreactivity is seen as fiber-like- staining (brown) on microtubule.
    Optimal Staining With TE Buffer, pH 9.0, Epitope Retrieval: Human Cerebellum
    使用声明
    • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
    储存和货运信息
    存储条件 Maintain at -20ºC in undiluted aliquots for up to 6 months after date of receipt. Avoid repeatedfreeze/thaw cycles.
    包装信息
    数量 100 µL

    merck millipore,默克密理博,AB5622,Anti-Microtubule-Associated Protein 2 (MAP2) Antibody

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